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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2024-15-3-33-41</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-1855</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Изучение особенностей вегетативного гомеостаза у больных анкилозирующим спондилитом с расстройствами тревожно-депрессивного спектра</article-title><trans-title-group xml:lang="en"><trans-title>To study the features of vegetative homeostasis in patients with ankylosing spondylitis with anxiety-depressive spectrum disorders</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9220-5841</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Благинина</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Blaginina</surname><given-names>I. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Благинина Ирина Ивановна, к.м.н., доцент; доцент кафедры внутренней медицины Факультета Последипломного Образования</p><p>Луганск, ЛНР</p></bio><bio xml:lang="en"><p>Irina I. Blaginina, Cand. Sci. (Med.), associate professor; associate professor, Department of internal medicine, Faculty of Postgraduate Education</p><p>Luhansk, LPR</p></bio><email xlink:type="simple">barry1803irina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Луганский государственный медицинский университет имени Святителя Луки</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Luhansk State Medical University n.a. St. Luke</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>10</day><month>07</month><year>2024</year></pub-date><volume>15</volume><issue>3</issue><fpage>33</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Благинина И.И., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Благинина И.И.</copyright-holder><copyright-holder xml:lang="en">Blaginina I.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/1855">https://www.medicalherald.ru/jour/article/view/1855</self-uri><abstract><p>Цель: исследование показателей вегетативного гомеостаза и психосоциального функционирования у больных анкилозирующим спондилитом (АС) с расстройствами тревожно-депрессивного спектра (РТДС).Материалы и методы: в исследовании приняли участие 112 пациентов с АС у которых оценивали наличие РТДС по шкалам Тейлора, Гамильтона, Спилбергера, вегетативные нарушения путём тестирования по методикам «Вейн-пациент» (ВП) и «Вейн-врач»(ВВ), вариабельность сердечного ритма (ВСР), качество жизни (КЖ) и клинико-лабораторную активность заболевания.Результаты: у большей части пациентов с АС выявлены признаки РТДС, при этом у данной категории пациентов установлены признаки вегетативной дисфункции, более низкие показатели жизненной активности, способности к адаптированному социальному функционированию и уровень психического здоровья. Полученные у данной категории больных показатели ВСР свидетельствуют о разбалансировке симпатических и парасимпатических влияний с доминированием симпатического звена регуляции, что подтверждает проведённый корреляционный анализ.Выводы: для больных АС с РТДС характерными являются низкая жизненная активность, снижение адаптации к социальному функционированию, истощение антиоксидантного потенциала. Для них характерно ухудшение показателей ВСР с превалированием симпатического звена ВНС, низкая устойчивость к психоэмоциональному напряжению с преобладанием оборонительного компонента в структуре вегетативной обеспеченности.</p></abstract><trans-abstract xml:lang="en"><p>Objective: study of indicators of vegetative homeostasis and psychosocial functioning in patients with ankylosing spondylitis (AS) with anxiety-depressive spectrum disorders (RTDS).Materials and methods: the study involved 112 patients with AS in whom the presence of RTDS was assessed according to the Taylor, Hamilton, Spielberger scales, autonomic disorders by testing according to the methods “Wayne-patient” (VP) and “Wayne-doctor” (BB), heart rate variability (HRV), quality of life (QOL) and clinical and laboratory activity of the disease.Results: the majority of patients with AS showed signs of RTDS, while this category of patients showed signs of autonomic dysfunction, lower indicators of vital activity, the ability to adapt social functioning and the level of mental health. The HRV indicators obtained in this category of patients indicate an imbalance of sympathetic and parasympathetic influences with the dominance of the sympathetic link of regulation, which confirms the correlation analysis.Conclusions: patients with AS with RTDS are characterized by low vital activity, reduced adaptation to social functioning, depletion of antioxidant potential. They are characterized by a deterioration in HRV indicators with a predominance of the sympathetic link of the ANS, low resistance to psychoemotional stress with a predominance of the defensive component in the structure of vegetative security.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>анкилозирующий спондилит</kwd><kwd>вегетативный гомеостаз</kwd><kwd>качество жизни</kwd><kwd>расстройства тревожно-депрессивного спектра</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ankylosing spondylitis</kwd><kwd>vegetative homeostasis</kwd><kwd>quality of life</kwd><kwd>anxiety-depressive spectrum disorders</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Абдрахманова А.И., Зарипова Ф.А., Амиров Н.Б. Расстройства тревожно-депрессивного спектра при ревматических заболеваниях. 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