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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2023-14-3-59-65</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-1770</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>3.1.22 ИНФЕКЦИОННЫЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>3.1.22 INFECTIOUS DISEASES</subject></subj-group></article-categories><title-group><article-title>Милуокский протокол — от идеи до реализации</article-title><trans-title-group xml:lang="en"><trans-title>Milwaukee Protocol — from idea to implementation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-5337-1638</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старков</surname><given-names>Ф. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Starkov</surname><given-names>F. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Старков Фёдор Игоревич - клинический ординатор.</p><p>Уфа</p></bio><bio xml:lang="en"><p>Fyodor I. Starkov - clinical resident of Bashkir State Medical University.</p><p>Ufa</p></bio><email xlink:type="simple">fed.starkov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4361-8674</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шалин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shalin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шалин Владислав Витальевич - клинический ординатор.</p><p>Пенза</p></bio><bio xml:lang="en"><p>Vladislav V. Shalin - clinical resident of PIUV – branch of FGBOU DPO RMANPO of the Ministry of Health of Russia.</p><p>Penza</p></bio><email xlink:type="simple">vladshalin190@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронов</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironov</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Миронов Владимир Сергеевич - заведующий отделением, врач травматолог-ортопед.</p><p>Пенза</p></bio><bio xml:lang="en"><p>Vladimir S. Mironov - Head of the department, traumatologist-orthopedist of "Clinical Hospital No. 6 named after G.A. Zakharin".</p><p>Penza</p></bio><email xlink:type="simple">mvs783@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Миронов Александр Владимирович - врач травматолог-ортопед.</p><p>Пенза</p></bio><bio xml:lang="en"><p>Alexander V. Mironov - traumatologist-orthopedist of "Clinical Hospital No. 6 named after G.A. Zakharin".</p><p>Penza</p></bio><email xlink:type="simple">mir.on.off.mironov@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Башкирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FGBOU VO "Bashkir State Medical University"</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Пензенский институт усовершенствования врачей – филиал федерального государственного бюджетного образовательного учреждения дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Penza Institute of Advanced Training of Doctors is a branch of the Federal State Budgetary educational Institution of Additional Professional Education "Russian Medical Academy of Continuing Professional Education" of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Клиническая больница №6 им. Г.А. Захарьина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Hospital No. 6 n. a. G.A. Zakharin</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>22</day><month>08</month><year>2023</year></pub-date><volume>14</volume><issue>3</issue><fpage>59</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Старков Ф.И., Шалин В.В., Миронов В.С., Миронов А.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Старков Ф.И., Шалин В.В., Миронов В.С., Миронов А.В.</copyright-holder><copyright-holder xml:lang="en">Starkov F.I., Shalin V.V., Mironov V.S., Mironov A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/1770">https://www.medicalherald.ru/jour/article/view/1770</self-uri><abstract><p>Несмотря на то, что бешенство в современном мире является редким спорадическим заболеванием, актуальность методов его лечения не подлежит сомнению, так как при отсутствии своевременной профилактики оно характеризуется 100%-ной летальностью. По состоянию на 2020 г. имеется около 70 случаев применения экспериментальных протоколов лечения бешенства, по данным Milwaukee Protocol Rabies Registry. Сама идея о том, что человеческий организм может должен сам справляться с вирусом, витала давно. Ещё до появления милуокского протокола были попытки лечения на стадии клинических проявлений. Первым стал Майкл Хаттвик из Центра контроля за инфекционными заболеваниями в Атланте, хотя научное сообщество до сих пор спорит, было ли это действительно бешенство. Суть данного протокола — это введение пациента в искусственную кому, введение противовирусных препаратов, симптоматическая терапия (антикольвусанты, ИВЛ и т.п.). На данный момент существует шестая версия Милуокского протокола (от 2018 г.), где даны общие рекомендации по его ведению, так как доказательная база слишком мала, чтобы можно было сделать какие-то общие выводы.</p></abstract><trans-abstract xml:lang="en"><p>Despite the fact that rabies in the modern world is a rare sporadic disease, the relevance of its methods of treatment is beyond doubt, since in the absence of timely prevention, it is characterized by 100% mortality. As of 2020, there are about 70 cases of experimental rabies treatment protocols according to the Milwaukee Protocol Rabies Registry. The very idea that the human body can cope with the virus itself has been around for a long time. Even before the advent of the Milwaukee protocol, there were attempts at treatment at the stage of clinical manifestations. The first was Michael Huttwick of the Center for Infectious Disease Control in Atlanta, although the scientific community is still arguing whether it was really rabies. The essence of this protocol is the introduction of a patient into an artificial coma, the introduction of antiviral drugs, symptomatic therapy (anticolvusants, mechanical ventilation, etc.). At the moment, there is the sixth version of the Milwaukee Protocol (from 2018), which provides general recommendations for its maintenance, since the material base is too small to draw any general conclusions.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бешество</kwd><kwd>вирус</kwd><kwd>лечение</kwd><kwd>Милуокский протокол</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rabies</kwd><kwd>virus</kwd><kwd>treatment</kwd><kwd>Milwaukee Protocol</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Змушко Е.И., Шувалова Е.П., Беляева Т.В., Белозеров Е.С. Инфекционные болезни. Учебник для студентов медицинских вузов. 2015</mixed-citation><mixed-citation xml:lang="en">Zmushko E. 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