mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2023-14-2-76-83mvjr-1719Research ArticleПЕДИАТРИЯPAEDIATRICSМультисистемный воспалительный синдром или Кавасаки-подобный синдром у детей, ассоциированный с COVID-19Multisystem inflammatory syndrome (MIS) or Kawasaki-like syndrome associated with COVID-19https://orcid.org/0000-0001-7043-9789БесединаЕ. А.BesedinaE. A.

Елена Алексеевна Беседина, к. м. н., доцент

кафедра детских болезней № 1

Ростов-на-Дону

Elena A. Besedina, Cand. Sci. (Med.), Associate Professor, Associate Professor of the Department

Department of Children's Diseases No. 1

Rostov-on-Don

besedina-dasha@yandex.ruhttps://orcid.org/0000-0003-4754-8156БадьянА. С.BadyanA. S.

Александра Сергеевна Бадьян, к. м. н., доцент

кафедра детских болезней № 1

Ростов-на-Дону

Aleksandra S. Badyan, Cand. Sci. (Med.), Associate Professor

Department of Childhood Diseases No. 1

Rostov-on-Don

alex.badyan@yandex.ruhttps://orcid.org/0000-0002-4636-7612ПискуноваС. Г.PiskunovaS. G.

Светлана Геннадьевна Пискунова, к. м. н.

Ростов-на-Дону

Svetlana G. Piskunova, Cand. Sci. (Med.), Associate Professor

Rostov-on-Don

odbrnd@donpac.ruhttps://orcid.org/0000-0003-3205-5148ДудниковаЭ. В.DudnikovaE. V.

Элеонора Васильевна Дудникова, д. м. н., профессор, заведующий кафедрой

кафедра детских болезней № 1

Ростов-на-Дону

Eleonora V. Dudnikova, Dr. Sci. (Med.), Professor, Head of the Department

Department of Children's Diseases No. 1

Rostov-on-Don

kaf.det.bol.1@yandex.ruhttps://orcid.org/0000-0002-8795-336XКоваленкоВ. Н.KovalenkoV. N.

Василиса Николаевна Коваленко, студент

Ростов-на-Дону

Vasilisa N. Kovalenko, student

Department of Childhood Diseases No. 1

Rostov-on-Don

Kovalenko_v@inbox.ruhttps://orcid.org/0009-0008-7755-9343ИнкинА. М.InkinA. M.

Алексей Михайлович Инкин, студент

Ростов-на-Дону

Alexey M. Inkin, student

Department of Childhood Diseases No. 1

Rostov-on-Don

inkina.lena@yandex.ruРостовский государственный медицинский университетРоссияRostov State Medical UniversityRussian Federation2023280620231427683Copyright © Беседина Е.А., Бадьян А.С., Пискунова С.Г., Дудникова Э.В., Коваленко В.Н., Инкин А.М., 20232023Беседина Е.А., Бадьян А.С., Пискунова С.Г., Дудникова Э.В., Коваленко В.Н., Инкин А.М.Besedina E.A., Badyan A.S., Piskunova S.G., Dudnikova E.V., Kovalenko V.N., Inkin A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1719

   С появлением вируса SARS-CoV-2 с декабря 2019 г. все страны мира начали активное внедрение различных стратегий для предотвращения его распространения и интенсивного поиска эффективных методов лечения. Первоначально рассматривались тяжёлые случаи заболевания только у взрослых, однако позже появилась информация о тяжёлом течении патологии у детей и подростков. Данное состояние, возникающее в рамках перенесённого COVID-19, получило название мультисистемный воспалительный синдром (МВС), или Кавасаки-подобный синдром. Имеющиеся результаты исследований указывают на то, что МВС является результатом врождённого и адаптивного иммунного ответа, характеризующегося цитокиновым штормом и отсроченным иммунологическим ответом на SARS-CoV-2.  Эидемиологические, клинические и иммунологические различия классифицируют МВС как отличный от болезни Кавасаки (БК) синдром, включая возрастной диапазон, а также географическое и этническое распределение пациентов. Необходимо отметить, что новые данные от пациентов с МВС указывают на уникальные характеристики иммунологического ответа, а также клиническое сходство с другими воспалительными синдромами, которые могут служить ориентиром при поиске молекулярных механизмов, участвующих в МВС. В обзоре представлен анализ исследований по данной теме: особенности патогенеза, диагностики, методов лечения, а также дальнейшие направления изучения проблемы. Поиск механизмов развития МВС у детей продолжается, а, в свою очередь, врачебная настороженность, своевременная диагностика и лечение позволяют добиться наилучшего возможного результата для таких пациентов.

   With the emergence of the SARS-CoV-2 virus in December 2019, all countries around the world have implemented various strategies to prevent its spread and intensively search for effective treatments. Initially, severe cases of the disease were considered only in adults, but later information appeared on the severe course of the disease in children and adolescents. This condition, which occurs as part of the transferred COVID-19, is called multisystem inflammatory syndrome (MIS) or Kawasaki-like syndrome. The available data indicate that MVS is the result of an innate and adaptive immune response characterized by a cytokine storm and a delayed immunological response to SARS-CoV-2. Epidemiological, clinical, and immunological differences classify MVS as a distinct syndrome from Kawasaki disease (БК), including age range, and geographic and ethnic distribution of patients. It should be noted that new data from patients with MVS point to unique characteristics of the immunological response, as well as clinical similarities with other inflammatory syndromes, which can serve as a guide in the search for molecular mechanisms involved in MVS. This review presents an analysis of studies on this topic: features of pathogenesis, diagnosis, treatment methods, as well as further directions for studying the problem. The search for mechanisms for the development of MVS in children continues, and, in turn, medical alertness, timely diagnosis and treatment make it possible to achieve the best possible result for such patients.

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The authors declare that there are no conflicts of interest present.