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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2022-13-4-114-121</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-1700</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Особенности течения анкилозирующего спондилита в зависимости от психосоциального статуса и длительности заболевания</article-title><trans-title-group xml:lang="en"><trans-title>Features of the course of ankylosing spondylitis depending on the psychosocial status and duration of the disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9220-5841</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Благинина</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Blaginina</surname><given-names>I. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Благинина Ирина Ивановна – кандидат медицинских наук, доцент; доцент кафедры внутренней медицины Факультета Последипломного Образования.</p><p>Луганск, ЛНР</p></bio><bio xml:lang="en"><p>Irina I. Blaginina - Cand. Sci. (Med.), associate professor; associate professor, Department of internal medicine, Faculty of Postgraduate Education, Saint Luka Lugansk State Medical University.</p><p>Lugansk, LPR</p></bio><email xlink:type="simple">barry1803@yandex.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Луганский государственный медицинский университет имени Святителя Луки</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Luka Lugansk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>31</day><month>12</month><year>2022</year></pub-date><volume>13</volume><issue>4</issue><fpage>114</fpage><lpage>121</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Благинина И.И., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Благинина И.И.</copyright-holder><copyright-holder xml:lang="en">Blaginina I.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/1700">https://www.medicalherald.ru/jour/article/view/1700</self-uri><abstract><p>Цель: изучение влияния психосоциальных показателей и длительности заболевания на качество жизни (КЖ), расстройства тревожно-депрессивного спектра (РТДС) и клинико-лабораторную активность у пациентов с анкилозирующим спондилитом (АС). Материалы и методы: в исследовании приняли участие 112 пациентов с АС, у которых оценивали клинико-лабораторную активность заболевания, КЖ (SF-36), наличие РТДС по шкалам Тейлора, Гамильтона, Спилбергера и вегетативные нарушения в зависимости от длительности заболевания, уровня образования. Результаты: у большей части пациентов с АС выявлены признаки РТДС, при этом у лиц с высшим образованием (ВО) РТДС встречались значимо чаще, также у них наблюдался более высокий уровень выраженности тревожности и депрессии. У пациентов с ВО установлены более низкая жизненная активность, способность к адаптированному социальному функционированию и показатель психического здоровья. Изучение влияния длительности АС на КЖ позволило установить связь между увеличением длительности АС и снижением показателя психологического компонента здоровья. Выводы: большую склонность к развитию РТДС имеют пациенты мужского пола с более высоким уровнем образования, для которых характерны более низкие показатели КЖ, преимущественно психологического здоровья. Увеличение давности заболевания АС не влияет на развитие РТДС. При длительности АС более 10 лет снижаются показатели психоэмоционального и физического компонентов КЖ, отмечается тенденция к росту тревожности и депрессии, истощаются факторы антиоксидантной защиты, нарастает воспалительная активность и усиливается личностное восприятие боли.</p></abstract><trans-abstract xml:lang="en"><p>Purpose: to study the influence of psychosocial indicators and duration of the disease on the quality of life (QL), anxiety-depressive spectrum disorders (ADSD) and clinical and laboratory activity in patients with ankylosing spondylitis (AS). Materials and methods: the study involved 112 patients with AS. The author assessed clinical and laboratory activity of the disease, QOL (SF-36), the presence of ADSD (using the Taylor, Hamilton, and Spielberger scales), and autonomic disorders depending on the duration of the disease and the level of education. Results: in most patients with AS, signs of ADSD were detected, while in persons with higher education (HE), ADSD were significantly more common, and they had a higher level of anxiety and depression. Patients with HE have lower vital activity, the ability to adapt to social functioning, and an indicator of mental health. The study of the effect of AS duration on QL allowed the author to establish an association between an increase in AS duration and a decrease in the indicator of the psychological component of health. Conclusions: male patients with a higher level of education, who are characterized by lower indicators of QOL, mainly psychological health, have a greater tendency to develop ADSD. An increase in the duration of AS disease does not affect the development of ADSD. With the duration of AS for over 10 years, the indicators of the psycho-emotional and physical components of QOL decrease. There is a tendency in the increase in anxiety and depression levels, antioxidant protection factors are getting exhausted, inflammatory activity progresses, and personal perception of pain intensifies.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>анкилозирующий спондилит</kwd><kwd>психосоциальный статус</kwd><kwd>качество жизни</kwd><kwd>расстройства тревожно-депрессивного спектра</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ankylosing spondylitis</kwd><kwd>psychosocial status</kwd><kwd>quality of life</kwd><kwd>anxiety-depressive spectrum disorders</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шубина О.С., Уколова Л.А., Шабанова Н.А., Богодерова Л.А., Загоруйко Е.Н. Психосоматические соотношения при заболеваниях суставов аутоиммунной природы. 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