mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2014-2-5-12mvjr-164Research ArticleОБЗОРЫREVIEWВОЗМОЖНОСТИ СНИЖЕНИЯ БИОЛОГИЧЕСКОГО ВОЗРАСТА ПРИ СТАРЕНИИ. ЭТЮДЫ ОПТИМИЗМАTHE POSSIBILITY OF BIOLOGICAL AGE REDUCTION IN THE OLD. ETUDES OF OPTIMISMБыковА. Т.BykovA. T.МаляренкоТ. Н.MalyarenkoT. N.МаляренкоЮ. Е.MalyarenkoYu. E.Кубанский государственный медицинский университетРоссияKuban State medical universityRussian Federation20143006201402512Copyright © Быков А.Т., Маляренко Т.Н., Маляренко Ю.Е., 20142014Быков А.Т., Маляренко Т.Н., Маляренко Ю.Е.Bykov A.T., Malyarenko T.N., Malyarenko Y.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/164

Анализ зарубежной литературы показал, что при обучении пожилых людей принципам здорового образа жизни (ЗОЖ) уже через 3 месяца выполнения программы существенно улучшаются показатели качества жизни. Соблюдение пожилыми людьми основных принципов ЗОЖ удлиняет продолжительность жизни на 3-10 лет, причём эффект тем больше, чем раньше человек начинает придерживаться здорового поведения. Дозированное / умеренное ограничение калорийности пищи (на 25% от должного потребления энергии) способно снизить биологический возраст старых людейв среднем на 7 лет.

The analysis of literature data revealed that three-months teaching of elderly and old people the principles of healthy life style significantly improve quality their life. If ageing people order the main principles of a healthy life style, it can make their life span 3-10 years longer, and this effect is the greater, the earlier they start to adhere to a healthy behavior. Graduated / moderate, prolonged constraint of caloric value of food (on 25 per cent from due value of energy consumption) can lower the biological age in ageing people up to about 7 years

здоровый образ жизниограничение калорийности пищистарые людиснижение биологического возрастаhealthy life stylecaloric value of food constraintbiological age reductionthe oldReferencesArai H., Ouchi Y., Yokode M., et al. Toward the realization of a better aged society: Massages from gerontology and geriatrics//Geriatr. Gerontol. Int. 2012. Vol. 12. P. 16-22.Arai H., Ouchi Y., Yokode M., et al. Toward the realization of a better aged society: Massages from gerontology and geriatrics//Geriatr. Gerontol. Int. 2012. Vol. 12. P. 16-22.Myint P.K., Welch A.A. Healthier ageing//BMJ. 2012. Vol. 344. e214.Myint P.K., Welch A.A. Healthier ageing//BMJ. 2012. Vol. 344. e214.Partridge L. The new biology of ageing//Phil. Trans. R. Soc. 2010. Vol. 365. No. 1537. P. 147-154.Partridge L. The new biology of ageing//Phil. Trans. R. Soc. 2010. Vol. 365. No. 1537. P. 147-154.Zhao G., Guo S., SomelM., Khaitovich P. Evolution of human longevity uncoupled from caloric restriction mechanisms//PLoS One. 2014 Jan. 6. Vol. 9. No. 1. e81417.Zhao G., Guo S., SomelM., Khaitovich P. Evolution of human longevity uncoupled from caloric restriction mechanisms//PLoS One. 2014 Jan. 6. Vol. 9. No. 1. e81417.Li Y., Daniel M., Tollefsbol T.O. Epigenetic regulation of caloric restriction in aging//BMC Med. 2011. No 9. P. 98.Li Y., Daniel M., Tollefsbol T.O. Epigenetic regulation of caloric restriction in aging//BMC Med. 2011. No 9. P. 98.Tollefsbol T.O. Dietary epigenetics in cancer and aging//Cancer Treat Res. 2014. Vol. 159.Tollefsbol T.O. Dietary epigenetics in cancer and aging//Cancer Treat Res. 2014. Vol. 159.Willcox B.J. Successful aging: Is there hope?//CMAJ. 2012 Dec.11. Vol. 184. No. 18. P. 1973-1974.Willcox B.J. Successful aging: Is there hope?//CMAJ. 2012 Dec.11. Vol. 184. No. 18. P. 1973-1974.Sabia S., Singh-Manoux A., Hagger-Johnson G., et al. Influence of individual and combined healthy behaviours on successful aging//GMAJ. 2012. Vol. 184. P. 1985-1992.Sabia S., Singh-Manoux A., Hagger-Johnson G., et al. Influence of individual and combined healthy behaviours on successful aging//GMAJ. 2012. Vol. 184. P. 1985-1992.Baylis D., Bartlett D.B., Patel H.P., Roberts H.C. Understanding how we age: insight into inflammaging//Longevity & Healthspan. 2013. No 2. 8 p.Baylis D., Bartlett D.B., Patel H.P., Roberts H.C. Understanding how we age: insight into inflammaging//Longevity & Healthspan. 2013. No 2. 8 p.Willcox B.J., He Q., Chen R., et al. Midlife risk factors and healthy survival in men//JAMA. 2006. Vol. 296. P. 2343-2350.Willcox B.J., He Q., Chen R., et al. Midlife risk factors and healthy survival in men//JAMA. 2006. Vol. 296. P. 2343-2350.Trost S.G., Blair S.N., Khan K.M. Physical inactivity remains the greatest public health problem of 21st century: evidence, improved methods and solutions using the 7 investments that work as a framework//Br. J. Sports Med. 2014. Vol. 48. P. 169-170.Trost S.G., Blair S.N., Khan K.M. Physical inactivity remains the greatest public health problem of 21st century: evidence, improved methods and solutions using the 7 investments that work as a framework//Br. J. Sports Med. 2014. Vol. 48. P. 169-170.Ornish D., Lin J., Chan J.M., et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study//Lancet Oncol. 2013 Oct. Vol. 14. No 11.P. 112-1120.Ornish D., Lin J., Chan J.M., et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study//Lancet Oncol. 2013 Oct. Vol. 14. No 11.P. 112-1120.Fernandez A.F., Fraga M.F. The effects of the dietary polyfenol resveratrol on human healthy aging and lifespan//Epigenetics. 2011 Jul. Vol. 6. No. 7. P. 870-874.Fernandez A.F., Fraga M.F. The effects of the dietary polyfenol resveratrol on human healthy aging and lifespan//Epigenetics. 2011 Jul. Vol. 6. No. 7. P. 870-874.Savolainen., Kautiainen H., Miettola J., et al. Low quality of life and depressive symptoms are connected with an unhealthy lifestyle//Scand. J. Publ. Health. Sept. 18, 2013.Savolainen., Kautiainen H., Miettola J., et al. Low quality of life and depressive symptoms are connected with an unhealthy lifestyle//Scand. J. Publ. Health. Sept. 18, 2013.Nekmatpou D., Shamsi M., Zamani M. The effect of a healthy lifestyle program on the elderly's health in Arak//Indian J. Med. Sci. March-April 2013. Vol. 67. No. 3-4. 8 p.Nekmatpou D., Shamsi M., Zamani M. The effect of a healthy lifestyle program on the elderly's health in Arak//Indian J. Med. Sci. March-April 2013. Vol. 67. No. 3-4. 8 p.Blagosklonny M.V. Increasing healthy lifespan by suppressing aging in our lifetime//Cell Cycle. Dec. 15, 2010. Vol. 9. Issue 24. P. 4788-4794.Blagosklonny M.V. Increasing healthy lifespan by suppressing aging in our lifetime//Cell Cycle. Dec. 15, 2010. Vol. 9. Issue 24. P. 4788-4794.Södergren M. Lifestyle predictors of healthy ageing in men//Maturitas. 2013. Vol. 75. No. 2. P. 113-117.Södergren M. Lifestyle predictors of healthy ageing in men//Maturitas. 2013. Vol. 75. No. 2. P. 113-117.Hamer M., Lavoie K.L., Bacon S.L. Taking up physical activity in later life and healthy ageing: the English longitudinal study of ageing//Br. J. Sports Med. 2014. Vol. 48. P. 239-243.Hamer M., Lavoie K.L., Bacon S.L. Taking up physical activity in later life and healthy ageing: the English longitudinal study of ageing//Br. J. Sports Med. 2014. Vol. 48. P. 239-243.Roth L.W. Can we live longer by eating less?//Maturitas. 2012 Apr. Vol. 71. No. 4. P. 315-319.Roth L.W. Can we live longer by eating less?//Maturitas. 2012 Apr. Vol. 71. No. 4. P. 315-319.Redman L.M., Ravussin E. Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes//Antioxid. Redox Signal. 2011 Jan. 15. Vol.14. No. 2. P. 275-287.Redman L.M., Ravussin E. Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes//Antioxid. Redox Signal. 2011 Jan. 15. Vol.14. No. 2. P. 275-287.Сhrysohoou C., Stefanidis C. Longevity and diet. Myth or pragmatism?//Maturitas. 2013 Dec. Vol. 76. No. 4. P. 303-307.Сhrysohoou C., Stefanidis C. Longevity and diet. Myth or pragmatism?//Maturitas. 2013 Dec. Vol. 76. No. 4. P. 303-307.Redman L.M., Kraus W.E., Bhapkar M., et al. Energy requirements in nonobese men and women: results from CALERIE//Am. J. Clin. Nutrition. 2014. ajcn.065631.Redman L.M., Kraus W.E., Bhapkar M., et al. Energy requirements in nonobese men and women: results from CALERIE//Am. J. Clin. Nutrition. 2014. ajcn.065631.Rochon J., Bales C.W., Ravussin E., et al. Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy//J. Gerontol. A Biol. Sci. Med. Sci. 2011. Vol. 66. P. 97-98.Rochon J., Bales C.W., Ravussin E., et al. Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy//J. Gerontol. A Biol. Sci. Med. Sci. 2011. Vol. 66. P. 97-98.Redman L.M., Heilbronn L.K., Martin C.K., et al. Effect of caloric restriction with or without exercise on body composition and fat distribution//J. Clin. Endocrinol. Metab. 2007. Vol. 92. P. 865-872.Redman L.M., Heilbronn L.K., Martin C.K., et al. Effect of caloric restriction with or without exercise on body composition and fat distribution//J. Clin. Endocrinol. Metab. 2007. Vol. 92. P. 865-872.Civitarese A.E., Carling S., Neilbron L.K., et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans//PLoS Med. 2007. No. 4. P. e76.Civitarese A.E., Carling S., Neilbron L.K., et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans//PLoS Med. 2007. No. 4. P. e76.Lefevre M., Redman L.M., Heilbronn, et al. Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals//Aterosckerosis. 2009. Vol. 203. P. 2006-213.Lefevre M., Redman L.M., Heilbronn, et al. Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals//Aterosckerosis. 2009. Vol. 203. P. 2006-213.Heilbronn L.K., de Jonge L., Frisard M.I., et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial//JAMA. 2006. Vol. 295. P. 1539-1548.Heilbronn L.K., de Jonge L., Frisard M.I., et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial//JAMA. 2006. Vol. 295. P. 1539-1548.Buchowski M.S., Hongu N., Acra S., et al. Effect of modest caloric restriction on oxidative stress in women. A randomized trial//PLoS One. Octob. 05 2012. Vol. 7. No. 10. e47079.Buchowski M.S., Hongu N., Acra S., et al. Effect of modest caloric restriction on oxidative stress in women. A randomized trial//PLoS One. Octob. 05 2012. Vol. 7. No. 10. e47079.Gräff J., Kahn M., Samiel A., et al. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration//J. Neurosci. 22 May 2013. Vol. 33. No. 21. P. 8951-8960.Gräff J., Kahn M., Samiel A., et al. A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration//J. Neurosci. 22 May 2013. Vol. 33. No. 21. P. 8951-8960.Kerti L., Witte A.W., Winkler A., et al. Higher glucose levels associated with lower memory and reduced hippocampal microstructure//Neurol. Novemb. 12, 2013. Vol. 81. No. 20. P. 1746-1752.Kerti L., Witte A.W., Winkler A., et al. Higher glucose levels associated with lower memory and reduced hippocampal microstructure//Neurol. Novemb. 12, 2013. Vol. 81. No. 20. P. 1746-1752.Martin C.K., Anton S.D., Han H., et al. Examination of cognitive function during six months of calorie restriction: results of a randomized controlled trial//Rejuvenation Res. 2007. No. 10. P. 179-190.Martin C.K., Anton S.D., Han H., et al. Examination of cognitive function during six months of calorie restriction: results of a randomized controlled trial//Rejuvenation Res. 2007. No. 10. P. 179-190.Witte A.V., Fobker M., Gellner L., et al. Caloric restriction improves memory in elderly humans//Proceed. National Academ. Sci. (PNAS). Jan. 27, 2009. Vol. 106. No 4. P. 1255-1260.Witte A.V., Fobker M., Gellner L., et al. Caloric restriction improves memory in elderly humans//Proceed. National Academ. Sci. (PNAS). Jan. 27, 2009. Vol. 106. No 4. P. 1255-1260.Okereke O.I., Rosner B.A., Kim D.H., et al. Dietary fat types and 4-year cognitive change in community-dwelling older women//Ann. Neurol. 2012 Jule. Vol. 72. No. 1. P. 124-134.Okereke O.I., Rosner B.A., Kim D.H., et al. Dietary fat types and 4-year cognitive change in community-dwelling older women//Ann. Neurol. 2012 Jule. Vol. 72. No. 1. P. 124-134.Bykov A.T., Malyarenko T.N., Malyarenko Yu.E., et al. Conscious and unconscious sensory inflows allow effectively control the various functions of human organism//Spanish J. Psychol. 2006. No. 2. P. 201-218.Bykov A.T., Malyarenko T.N., Malyarenko Yu.E., et al. Conscious and unconscious sensory inflows allow effectively control the various functions of human organism//Spanish J. Psychol. 2006. No. 2. P. 201-218.Sofiadis N.Th., Malyarenko T.N. Principles of forming of the programs of motor activity for health rehabilitation (ed. Yu.E.Malyarenko). Thessaloniki: University Studio Press, 2008.111 p.Sofiadis N.Th., Malyarenko T.N. Principles of forming of the programs of motor activity for health rehabilitation (ed. Yu.E.Malyarenko). Thessaloniki: University Studio Press, 2008.111 p.Быков А.Т. Восстановительная медицина и экология человека. -М.: ГЭОТАР-Медиа, 2009. -688 с.Быков А.Т. Восстановительная медицина и экология человека. -М.: ГЭОТАР-Медиа, 2009. -688 с.

The authors declare that there are no conflicts of interest present.