mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2023-14-1-119-124mvjr-1639Research ArticleАЛЛЕРГОЛОГИЯ И ИММУНОЛОГИЯALLERGOLOGY AND IMMUNOLOGYРоль фактора роста нервов (NGF) в патогенезе лепрыThe role of nerve growth factor (NGF) in the pathogenesis of leprosyhttps://orcid.org/0000-0001-8423-3351ЛуценкоА. В.LutsenkoA. V.

Луценко Анна Викторовна, к.б.н., научный сотрудник отдела по изучению лепры, ассистент кафедры «Клиническая иммунология с курсом последипломного образования»; доцент кафедры «Прикладная биология и микробиология» 

Астрахань

Anna V. Lutsenko, Cand. Sci. (Biol.), Researcher of the Leprosy Department; Assistant of the Department “Clinical immunology with a course of postgraduate education”, Astrakhan State Medical University, Associate Professor of the Department of Applied Biology and Microbiology 

Astrakhan

ahrapova@yandex.ruhttps://orcid.org/0000-0002-4426-3860СароянцЛ. В.SaroyantsL. V.

Сароянц Людмила Валентиновна, д.м.н., заведующая отделом по изучению лепры; профессор кафедры физиологии, морфологии, генетики и биомедицины

Астрахань

Liudmila V. Saroyants, Dr. Sci. (Med.), Head of the Leprosy Department, and Professor of the Department of Physiology, Morphology, Genetics and Biomedicine 

Astrakhan

luda_saroyants@mail.ruАстраханский государственный медицинский университет; Астраханский государственный технический университетРоссияAstrakhan State Medical University; Astrakhan State Technical UniversityRussian FederationАстраханский государственный медицинский университет; Астраханский государственный университетРоссияAstrakhan State Medical University; Astrakhan State UniversityRussian Federation202328032023141119124Copyright © Луценко А.В., Сароянц Л.В., 20232023Луценко А.В., Сароянц Л.В.Lutsenko A.V., Saroyants L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1639

Лепра — хроническое инфекционное заболевание, вызываемое M. leprae, с преимущественным поражением кожи и периферической нервной системы. В настоящее время лепра в основном диагностируется клиницистами с использованием бактериоскопических исследований скарификатов и биопсии кожи. Однако разработка и применение новых диагностических критериев, особенно связанных с повреждением нервных волокон, остается актуальной задачей современной лепрологии. В настоящем обзоре рассмотрена важная роль нейротрофического фактора (фактор роста нервов, NGF) в патогенезе поражения нервной системы при лепре, установлена взаимосвязь уровней NGF с формами заболевания. В обзор включены данные зарубежных и отечественных статей, поиск проводился по базам данных “Scopus”, “PubMed”, “Web of Science”, “elIBRARY”.

Leprosy is a chronic infectious disease caused by M. leprae with a primary lesion of the skin and peripheral nervous system. Currently, clinicians using bacterioscopic studies of scarification and skin biopsy mainly diagnose leprosy. However, the development and application of new diagnostic criteria, especially those associated with damage to nerve fibers, remains an urgent task of modern leprology. This review considers the important role of neurotrophic factor (nerve growth factor, NGF) in the pathogenesis of nervous system damage in leprosy and establishes the relationship between NGF levels and forms of the disease. The review includes data from foreign and domestic articles; the search was carried out using the “Scopus”, “PubMed”, “Web of Science”, “elIBRARY” databases.

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The authors declare that there are no conflicts of interest present.