mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2022-13-3-137-147mvjr-1548Research ArticleКЛИНИЧЕСКАЯ ИММУНОЛОГИЯ, АЛЛЕРГОЛОГИЯCLINICAL IMMUNOLOGY, ALLERGOLOGYБиомаркеры анафилаксииBiomarkers of anaphylaxishttps://orcid.org/0000-0001-8792-2670ЕсаковаН. В.EsakovaN. V.

Есакова Наталья Владиславовна – кандидат медицинских наук, старший научный сотрудник отдела аллергологии и клинической иммунологии, НИКИ педиатрии им. ак. Ю.Е. Вельтищева РНИМУ им. Н.И. Пирогова Минздрава России.

Москва.

Natalia V. Esakova - Cand. Sci. (Med.), Senior researcher, Allergy and Clinical Immunology Department, Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University.

Moscow.

env007@rambler.ruhttps://orcid.org/0000-0003-4525-1500ЛебеденкоА. А.LebedenkoA. A.

Лебеденко Александр Анатольевич - доктор медицинских наук, профессор, заведующий кафедрой детских болезней №2.

Ростов-на-Дону.

Alexander A. Lebedenko - Dr. Sci. (Med.), Professor, head of Department of childhood diseases № 2, Rostov State Medical University.

Rostov-on-Don.

leb.rost@rambler.ruhttps://orcid.org/0000-0001-5039-8473ПампураА. Н.PampuraA. N.

Пампура Александр Николаевич – доктор медицинских наук, профессор, заведующий отделом аллергологии и клинической иммунологии Научно-исследовательский клинический институт педиатрии им. ак. Ю.Е. Вельтищева РНИМУ им. Н.И. Пирогова Минздрава России.

Москва.

Alexander N. Pampura - Dr. Sci. (Med.), Professor, Head of Allergy and Clinical Immunology Department, Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University.

Moscow.

apampura@pedklin.ruНаучно-исследовательский клинический институт педиатрии им. ак. Ю.Е. Вельтищева РНИМУ им. Н.И. Пирогова Минздрава РоссииРоссияVeltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical UniversityRussian FederationРостовский Государственный Медицинский УниверситетРоссияRostov State Medical UniversityRussian Federation202230092022133137147Copyright © Есакова Н.В., Лебеденко А.А., Пампура А.Н., 20222022Есакова Н.В., Лебеденко А.А., Пампура А.Н.Esakova N.V., Lebedenko A.A., Pampura A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1548

Анафилаксия представляет собой тяжёлую, угрожающую жизни, системную реакцию гиперчувствительности, которая развивается быстро и может привести к смерти. Диагноз «Анафилаксия» продолжает оставаться в первую очередь клиническим. В этой связи ежегодно инициируется значительное количество исследовательских работ, направленных на более глубокое изучение механизмов развития данного заболевания и поиск его биомаркеров, которые могли бы стать важным инструментом для облегчения верификации диагноза, профилактики и оценки риска повторных эпизодов анафилаксии, стратификации тяжести её течения, риска развития жизнеугрожающих/летальных эпизодов системных реакций и иметь ключевое значение в разработке новых терапевтических стратегий. В данном обзоре представлена исчерпывающая информация в отношении имеющихся на сегодня данных о потенциальных биомаркерах анафилаксии.

Anaphylaxis is a severe, life-threatening, systemic hypersensitivity reaction that develops rapidly and can lead to death. The diagnosis of anaphylaxis continues to be primarily clinical. Therefore, a large number of studies are initiated annually aimed at a deeper study of the mechanisms of the development of this disease and the search for its biomarkers, which could become an important tool to facilitate the verification of diagnosis, prevention and risk assessment of repeated episodes of anaphylaxis, stratification of the severity of its course, the risk of life-threatening episodes of systemic reactions, and be important in the development of new therapeutic strategies. This review provides information on the currently available data on potential biomarkers of anaphylaxis.

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The authors declare that there are no conflicts of interest present.