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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2022-13-3-183-187</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-1525</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Особенности клинического течения и диагностика инфекционного эндокардита у пожилых людей</article-title><trans-title-group xml:lang="en"><trans-title>Clinical course and features of the diagnosis of infectious endocarditis in the elderly</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7105-7501</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степченко</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepchenko</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Степченко Марина Александровна – доктор медицинских наук, профессор кафедры внутренних болезней №1.</p><p>Курск.</p></bio><bio xml:lang="en"><p>Marina A. Stepchenko - Dr. Sci. (Med.), Professor of the Department Internal Diseases 1, Kursk State Medical University.</p><p>Kursk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9292-3093</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мещерина</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Meshcherina</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мещерина Наталья Сергеевна - доктор медицинских наук, заведующая кафедрой внутренних болезней №1.</p><p>Курск.</p></bio><bio xml:lang="en"><p>Natalia S. Meshcherina - Dr. Sci. (Med.), The Head of the Department Internal Diseases 1, Kursk State Medical University.</p><p>Kursk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8317-322X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хардикова</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Hardikova</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хардикова Елена Михайловна – кандидат медицинских наук, доцент кафедры внутренних болезней №1.</p><p>Курск.</p></bio><bio xml:lang="en"><p>Elena M. Hardikova - Cand. Sci. (Med.), Docent of the Department Internal Diseases 1, Kursk State Medical University.</p><p>Kursk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5839-3087</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Москалюк</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Moskalyuk</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москалюк Майя Игоревна - врач-кардиолог высшей квалификационной категории.</p><p>Курск.</p></bio><bio xml:lang="en"><p>Maya I. Moskalyuk - Сardiologist of the highest qualification category, Kursk Regional Multidisciplinary Clinical Hospital.</p><p>Kursk.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1864-3309</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мальцева</surname><given-names>И. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Maltseva</surname><given-names>I. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мальцева Ирина Олеговна - студентка 5 курса лечебного факультета.</p><p>Курск.</p></bio><bio xml:lang="en"><p>Irina O. Maltseva - 5th year student of the Faculty of Medicine, Kursk State Medical University.</p><p>Kursk.</p></bio><email xlink:type="simple">irina061099@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Курский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kursk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Курская областная многопрофильная клиническая больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kursk Regional Multidisciplinary Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2022</year></pub-date><volume>13</volume><issue>3</issue><fpage>183</fpage><lpage>187</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Степченко М.А., Мещерина Н.С., Хардикова Е.М., Москалюк М.И., Мальцева И.О., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Степченко М.А., Мещерина Н.С., Хардикова Е.М., Москалюк М.И., Мальцева И.О.</copyright-holder><copyright-holder xml:lang="en">Stepchenko M.A., Meshcherina N.S., Hardikova E.M., Moskalyuk M.I., Maltseva I.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/1525">https://www.medicalherald.ru/jour/article/view/1525</self-uri><abstract><p>Инфекционный эндокардит — грозное заболевание, характеризующееся крайне неблагоприятным прогнозом при естественном его течении. Анализируя литературные данные, можно отметить, что частота инфекционного эндокардита в Российской Федерации имеет сравнительно высокие показатели распространенности по отношению к другим странам. В настоящее время проблема ранней диагностики этого заболевания остается актуальной. Несмотря на то, что диагностика инфекционного эндокардита улучшилась, в основном, в результате усовершенствования эхокардиографического и микробиологического подходов, внедрение в клиническую практику новых антибактериальных препаратов и кардиохирургических технологий, клиническая картина, изменения в лабораторных показателях могут направить в русло исключения иммуновоспалительных, ревматических, онкологических, гематологических заболеваний, затрудняя и затягивая диагностику. Первые клинические признаки могут быть неспецифичны, и болезнь остается нераспознанной в течение недель или даже месяцев. Высокая частота тромботических, тромбогеморрагических осложнений указывает на глубокие изменения в системе гемостаза при инфекционном эндокардите и необходимость раскрытия патогенеза указанных нарушений. Совокупность этих факторов привела к поздней диагностике данного заболевания у пациентки. Цель исследования — изучение возможности улучшения результатов диагностики и терапии пациентов с инфекционным эндокардитом в клинической практике.</p></abstract><trans-abstract xml:lang="en"><p>Infectious endocarditis is a formidable disease characterized by an extremely unfavorable prognosis in its natural course. Analyzing the literature data, it can be noted that the frequency of infectious endocarditis in the Russian Federation has relatively high prevalence rates in relation to other countries. Currently, the problem of early diagnosis of infectious endocarditis remains relevant. Despite the fact that the diagnosis of infectious endocarditis has improved, mainly as a result of the improvement of echocardiographic and microbiological approaches, the introduction of new antibacterial drugs and cardiac surgery technologies into clinical practice, the clinical picture, changes in laboratory parameters can lead to the exclusion of immuno-inflammatory, rheumatic, oncological, hematological diseases, complicating and delaying the diagnosis of infectious endocarditis. The first clinical signs of infectious endocarditis may be nonspecific, and the disease remains unrecognized for weeks or even months. The high frequency of thrombotic, thrombohemorrhagic complications indicates profound changes in the hemostasis system in infectious endocarditis and the need to disclose the pathogenesis of these disorders. The combination of these factors led to the late diagnosis of this disease in the patient. The aim of the study is to study the possibility of improving the results of diagnosis and therapy of patients with infectious endocarditis in clinical practice.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекционный эндокардит</kwd><kwd>диагностика</kwd><kwd>диагностические ошибки</kwd><kwd>лечение инфекционного эндокардита</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infectious endocarditis</kwd><kwd>diagnosis</kwd><kwd>diagnostic errors</kwd><kwd>treatment of infectious endocarditis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Baddour LM, Wilson WR, Bayer AS, Fowler VG Jr, Tleyjeh IM, et al. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation. 2015;132(15):1435-86. 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