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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2022-13-2-146-153</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-1496</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>3.1.17 ПСИХИАТРИЯ И НАРКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PSYCHIATRY AND NARCOLOGY</subject></subj-group></article-categories><title-group><article-title>Клинические особенности сочетания агорафобии и психических расстройств непсихотического уровня</article-title><trans-title-group xml:lang="en"><trans-title>Clinical features of the combination of agoraphobia and non-psychotic mental disorders</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6412-020X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ковалев</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovalev</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ковалев Александр Иванович, ассистент кафедры психиатрии</p><p>Ростов-на-Дону </p></bio><bio xml:lang="en"><p>Kovalev Alexander Ivanovich, Assistant of the Department of Psychiatry</p><p>Rostov-on-Don</p></bio><email xlink:type="simple">aik_psych@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ростовский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>06</day><month>07</month><year>2022</year></pub-date><volume>13</volume><issue>2</issue><fpage>146</fpage><lpage>153</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ковалев А.И., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ковалев А.И.</copyright-holder><copyright-holder xml:lang="en">Kovalev A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/1496">https://www.medicalherald.ru/jour/article/view/1496</self-uri><abstract><p>В обзоре дается современное определение понятия «агорафобия». Представлены разные классификационные подходы в типировании агорафобии. Показана ее роль как фактора, утяжеляющего течение психических расстройств непсихотического уровня. Проанализированы особенности проявления в зависимости от нозологической принадлежности. Выявлено, что агорафобия является предиктором неблагоприятного исхода у лиц с паническим расстройством. В свою очередь паническое расстройство часто становится причиной развития агорафобии. При этом отмечаются гендерные и возрастные аспекты. Показана коморбидность агорафобии и сомато-вегетативного типа генерализованного тревожного расстройства. Агорафобия повышает риск формирования суицидального поведения при депрессии, имеет высокую корреляцию с выраженностью личностных расстройств, особенно избегающего и зависимого типа. При этом некоторые исследователи оспаривают точку зрения, что данные виды расстройств личности являются предрасполагающими факторами для панического расстройства и агорафобии, основываясь на ретроспективных данных по преморбидной структуре личностей пациентов с тревожными расстройствами. Взаимосвязь между посттравматическим стрессовым расстройством и паническим расстройством подчеркивается в связи с появлением циркулярной модели развития чувства страха, которая постулирует сходную этиологию тревожных расстройств. Имеется коморбидность агорафобии с расстройствами ипохондрического спектра: от степени фиксации до навязчивого характера. Снижает эффективность терапии расстройств шизофренического спектра и качество жизни больных. Картина самого панического расстройства с агорафобией утяжеляется при наличии у пациента хронического алкоголизма, при этом наличие агорафобической симптоматики приводит к рецидиву алкогольной болезни, что объясняется приемом спиртного для облегчения симптомов, а также повышает вероятность развития зависимости от транквилизаторов.</p></abstract><trans-abstract xml:lang="en"><p>The review article gives a modern definition of the concept of agoraphobia. Different classification approaches in the typing of agoraphobia are presented. Its role as a factor aggravating the course of non-psychotic mental disorders is shown. The features of its manifestation depending on the nosological affiliation are analyzed. It was revealed that agoraphobia is a predictor of an unfavorable outcome in people with panic disorder. In turn, panic disorder often causes the development of agoraphobia. At the same time, gender and age aspects are noted. The comorbidity of agoraphobia and somato-vegetative type of generalized anxiety disorder is shown. Agoraphobia increases the risk of suicidal behavior in depression, has a high correlation with the severity of personality disorders, especially of the avoidant and dependent type. At the same time, some researchers dispute the point of view that these types of personality disorders are predisposing factors for panic disorder and agoraphobia, based on retrospective data on the premorbid personality structure of patients with anxiety disorders. The relationship between PTSD and panic disorder is emphasized in connection with the emergence of a circular model of the development of feelings of fear, which postulates a similar etiology of anxiety disorders. There is a comorbidity of agoraphobia with disorders of the hypochondriac spectrum: from the degree of fixation to obsessive nature. reduces the effectiveness of therapy for schizophrenic spectrum disorders and the quality of life of patients. The picture of the panic disorder itself with agoraphobia becomes heavier if the patient has chronic alcoholism (in particular, the frequency of seizures increases), while the presence of agoraphobic symptoms leads to a relapse of alcoholic illness, which is explained by taking alcohol to relieve symptoms, and also increases the likelihood of developing dependence on tranquilizers.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>агорафобия</kwd><kwd>тревожные расстройства</kwd><kwd>пограничные психические расстройства</kwd></kwd-group><kwd-group xml:lang="en"><kwd>agoraphobia</kwd><kwd>anxiety disorders</kwd><kwd>borderline mental disorders</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Segui j, Salvador-Carulla L, Marquez M, Garcia L, Canet j, et al. Differential clinical features of late-onset panic disorder. J Affect Disord. 2000;57(1-3):115-124. 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