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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2219-8075-2022-13-1-13-23</article-id><article-id custom-type="elpub" pub-id-type="custom">mvjr-1481</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭНДОКРИНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ENDOCRYNOLOGY</subject></subj-group></article-categories><title-group><article-title>Перспективные разработки в области дифференциальной диагностики доброкачественных и злокачественных узлов щитовидной железы</article-title><trans-title-group xml:lang="en"><trans-title>Promising developments in the fi eld of diff erential diagnosis of benign and malignant thyroid nodules</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9574-105X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ворохобина</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorokhobina</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Владимировна Ворохобина - доктор медицинских наук, проф., заведующая кафедрой эндокринологии им. акад. В.Г. Баранова, SPIN-code: 4062-6409.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Natalya V. Vorokhobina - Dr. Sci (Med.), Professor, Head of the V.G. Baranov Department of Endocrinology.</p><p>St. Petersburg</p></bio><email xlink:type="simple">natalya.vorokhobina@szgmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7826-7184</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранов</surname><given-names>В. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranov</surname><given-names>V. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баранов Виталий Леонидович - доктор медицинских наук, профессор кафедры эндокринологии им. акад. В.Г. Баранова.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Vitalii L. Baranov - Dr. Sci (Med.), Professor, Head of the V.G. Baranov Department of Endocrinology.</p><p>St. Petersburg</p></bio><email xlink:type="simple">Vitalii.Baranov@szgmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8734-2449</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фогт</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Fogt</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фогт Сергей Николаевич - кандидат медицинских наук, доцент кафедры эндокринологии им. акад. В.Г. Баранова.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Sergei N. Fogt - Cand. Sci (Med.), Associate Professor. the V.G. Baranov Department of Endocrinology.</p><p>St. Petersburg</p></bio><email xlink:type="simple">s_fogt@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4990-5946</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsova</surname><given-names>F. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузнецова Алла Васильевна - кандидат медицинских наук, доцент кафедры эндокринологии имени акад. В.Г. Баранова.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Alla V. Kuznetcova - Cand. Sci (Med.), Associate Professor. the V.G. Baranov Department of Endocrinology.</p><p>St. Petersburg</p></bio><email xlink:type="simple">Alla.Kuznetcova@szgmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1977-8299</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баландина</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Balandina</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баландина Ксения Александровна - кандидат медицинских наук, доцент кафедры эндокринологии имени акад. В.Г. Баранова.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Kseniya A. Balandina - Cand. Sci (Med.), Associate Professor. the V.G. Baranov Department of Endocrinology.</p><p>St. Petersburg</p></bio><email xlink:type="simple">ksenya_sautina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3599-3199</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галахова</surname><given-names>Р. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Galakhova</surname><given-names>R. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Галахова Равиля Камильевна - кандидат медицинских наук, доцент кафедры эндокринологии имени акад. В.Г. Баранова.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Ravilya K. Galakhova - Cand. Sci (Med.),  Associate Professor. the V.G. Baranov Department of Endocrinology.</p><p>St. Petersburg</p></bio><email xlink:type="simple">rgalakhova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Северо-Западный государственный медицинский Университет им. И.И. Мечникова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.I. Mechnikov North-Western State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2022</year></pub-date><volume>13</volume><issue>1</issue><fpage>13</fpage><lpage>23</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ворохобина Н.В., Баранов В.Л., Фогт С.Н., Кузнецова А.В., Баландина К.А., Галахова Р.К., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ворохобина Н.В., Баранов В.Л., Фогт С.Н., Кузнецова А.В., Баландина К.А., Галахова Р.К.</copyright-holder><copyright-holder xml:lang="en">Vorokhobina N.V., Baranov V.L., Fogt S.N., Kuznetsova F.V., Balandina K.A., Galakhova R.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/1481">https://www.medicalherald.ru/jour/article/view/1481</self-uri><abstract><p>В последние годы возможности определения природы узлов щитовидной железы были существенно улучшены посредством усовершенствования традиционных методов, таких как ультразвуковое исследование (УЗИ) и тонкоигольная аспирационная биопсия (ТАБ), а также путём создания принципиально новых подходов. В обзоре приведены наиболее актуальные достижения последних лет. Поиск литературы проведён в библиографической базе Российского индекса научного цитирования по словам «узел», «щитовидная железа», «диагностика», «рак» на сайте «https://www.elibrary.ru», а также в базе данных медицинских и биологических публикаций Национального центра биотехнологической информации США по словам «nodule», «thyroid», «diagnostics», «cancer» на сайте «https://pubmed.ncbi. nlm.nih.gov». Проведён анализ источников за последние 5 лет.</p></abstract><trans-abstract xml:lang="en"><p>In recent years, the ability to determine the nature of thyroid nodules has been signifi cantly improved both through the improvement of traditional methods, such as ultrasound examination (ultrasound) and fi ne needle aspiration biopsy (TAB), and through the creation of fundamentally new approaches. Th e review contains the most relevant achievements of recent years. Th e literature search was carried out in the bibliographic base of the Russian Science Citation Index for the words «node», «thyroid gland», «diagnosis», «cancer» on the site «https://www.elibrary.ru», as well as in the database of medical and Biological publications of the US National Center for Biotechnology Information on «nodule», «thyroid», «diagnostics», «cancer» at https://pubmed.ncbi.nlm.nih.gov. Th e analysis of sources for the last 5 years has been carried out.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>узел</kwd><kwd>щитовидная железа</kwd><kwd>диагностика</kwd><kwd>рак</kwd></kwd-group><kwd-group xml:lang="en"><kwd>review</kwd><kwd>nodule</kwd><kwd>thyroid gland</kwd><kwd>diagnostics</kwd><kwd>cancer</kwd></kwd-group><funding-group><funding-statement xml:lang="en">Th e study did not have sponsorship</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lim H, Devesa SS, Sosa JA, Check D, Kitahara CM. Trends in Th yroid Cancer Incidence and Mortality in the United States, 1974-2013. JAMA. 2017;317(13):1338-1348. DOI: 10.1001/jama.2017.2719</mixed-citation><mixed-citation xml:lang="en">Lim H, Devesa SS, Sosa JA, Check D, Kitahara CM. Trends in Th yroid Cancer Incidence and Mortality in the United States, 1974-2013. 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