mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2021-12-1-24-32mvjr-1321Research ArticleОБЗОРЫREVIEWНовые молекулярные мишени действия антидепрессантовThe new molecular targets for antidepressantshttps://orcid.org/0000-0002-8368-5644КузнецовЮ. В.KuznetsovYu. V.

Кузнецов Юрий Васильевич, к.м.н., доц., доцент кафедры фармакологии и клинической фармакологии им. проф. И.В. Комиссарова 

Донецк, ДНР

Yuriy V. Kuznetsov, Cand. Sci. (Med), associate Professor of the I.V. Komissarov Department of Pharmacology and Clinical Pharmacology 

Donetsk, DPR

far6@yandex.ruhttps://orcid.org/0000-0003-2989-7811ЕвдокимовД. В.EvdokimovD. V.

Евдокимов Дмитрий Владимирович, к.м.н., доц., доцент кафедры фармакологии и клинической фармакологии им. проф. И.В. Комиссарова 

Донецк, ДНР

Dmitriy V. Evdokimov, Cand. Sci. (Med), associate Professor of the I.V. Komissarov Department of Pharmacology and Clinical Pharmacology 

Donetsk, DPR

evdokimov.dmitr@yandex.ruhttps://orcid.org/0000-0002-2229-7541АбрамецИ. И.AbrametsI. I.

Абрамец Игорь Игоревич, д.м.н., проф., профессор кафедры фармакологии и клинической фармакологии им. проф. И.В. Комиссарова

Донецк, ДНР

Igor I. Abramets. Dr. Sci. (Med), full Professor of the I.V. Komissarov Department of Pharmacology and Clinical Pharmacology 

Donetsk, DPR

abramets4141@mail.ruДонецкий национальный медицинский университет им. М. ГорькогоУкраинаM. Gorkiy Donetsk National Medical UniversityUkraine2021290320211212432Copyright © Кузнецов Ю.В., Евдокимов Д.В., Абрамец И.И., 20212021Кузнецов Ю.В., Евдокимов Д.В., Абрамец И.И.Kuznetsov Y.V., Evdokimov D.V., Abramets I.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1321

Эффективность лечения депрессивных расстройств недостаточна. Это обусловлено неполным пониманием как патогенеза депрессии, так и механизмов действия антидепрессантов. Повышение эффективности лечения депрессивных расстройств тесно связано с получением более полных представлений о патогенезе заболевания и механизмах действия антидепрессантов. Первая линия действия применяемых сейчас антидепрессантов — накопление моноаминов и длительная активация мембранных рецепторов. Однако снижению плотности мембранных рецепторов, обусловленному включением гомеостатических механизмов вследствие длительной активации рецепторов, противодействует вторая линия активности антидепрессантов. Она связана с экспрессией под действием антидепрессантов индуцибельного регуляторного белка S100А10 (р11) и его партнёров. В обзоре рассмотрены структура и функции белка р11, его взаимодействие с белками аннексином А2, Ahnak, регулятором хроматина SMARCA3. Проанализировано влияние р11 на мембранную плотность серотониновых 5-НТ1В и 5-НТ4 рецепторов, метаботропных глутаматных рецепторов 5, потенциалозависимых калиевых Кv3 и кальциевых Саv1.2 и 1.3 каналов, которые играют существенную роль как в действии антидепрессантов, так и в патогенезе депрессивных расстройств. Системный поиск литературы проводился по базам данных Scopus, WebofScience, MedLine, elibrary и другим.

The efficacy of depressive disorders treatment is insufficient. It is explained by an incomplete understanding of both pathogenesis of depression and antidepressants mechanism action. An improvement of the treatment efficacy of depression disorders is closely associated with complete knowledge of the pathogenesis of disorders and antidepressant mechanism of action. The effect produced by the first line of antidepressants prescribed currently in the clinical practice includes the accumulation of monoamines and prolonged activation of their membrane receptors. However, a decrease in the membrane receptors density evoked by prolonged activation of monoaminergic receptors is counteracted by the second line of antidepressant activity. It is associated with the expression of inducible regulatory protein S100A10 (p11) and its partners. In this review, the authors examined the structure and function of protein p11, its interaction with such proteins as annexin A2, Ahnak, chromatinremodeling factor SMARCA3. The authors analyzed the influence of p11 on the membrane density of serotonin 5-HT1B and 5-HT4 receptors, metabotropic glutamate receptors 5, voltage-dependent potassium Kv3, and calcium Cav1.2 and 1.3 channels, that play an important role in both the effect of antidepressants and the pathogenesis of depression disorders. A systematic literature search was conducted in Scopus, Web of Science, MedLine, elibrary, and other databases.

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The authors declare that there are no conflicts of interest present.