mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2020-11-4-24-31mvjr-1307Research ArticleОБЗОРЫREVIEWВозможности и эффективность элиминации аллергенов домашних животных: мифы и реальностьThe capacity and effectiveness elimination domestic animals allergens: myths and realitieshttps://orcid.org/0000-0001-5039-8473ПампураА. Н.PampuraA. N.

д.м.н., заведующий отделом аллергологии и клинической иммунологии, 

Москва

Dr. Sci. (Med.), head of Department of Allergology and clinical immunology,

Moscow

apampura1@mail.ruhttps://orcid.org/0000-0003-0941-9871МигачеваН. Б.MigachevaN. B.

к.м.н., доцент кафедры педиатрии,

Самара

Can. Sci. (Med.), docent Department of Pediatrics,

Samara

nbmigacheva@gmail.comhttps://orcid.org/0000-0003-4295-725XВарламовЕ. Е.VarlamovE. E.

к.м.н., старший научный сотрудник отдела аллергологии и клинической иммунологии,

Москва

Can. Sci. (Med.), senior researcher of Department of Allergology and clinical immunology,

Moscow

evarlamov@pedklin.ruhttps://orcid.org/0000-0002-3116-6447АсмановА. И.AsmanovA. I.

к.м.н., руководитель научного отдела острой и хронической патологии уха, горла и носа обособленного структурного подразделения,

Москва

Can. Sci. (Med.), head of Department of Acute and chronic diseases of the ear, throat and nose,

Moscow

asmanov@pedklin.ruНаучно-исследовательский клинический институт педиатрии имени академика Ю.Е. ВельтищеваРоссияClinical Research Institute of PediatricsRussian FederationСамарский государственный медицинский университетРоссияSamara State Medical UniversityRussian Federation2020201220201142431Copyright © Пампура А.Н., Мигачева Н.Б., Варламов Е.Е., Асманов А.И., 20202020Пампура А.Н., Мигачева Н.Б., Варламов Е.Е., Асманов А.И.Pampura A.N., Migacheva N.B., Varlamov E.E., Asmanov A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1307

В настоящее время сенсибилизация к ингаляционным аллергенам домашних животных абсолютно правомерно считается одним из ключевых факторов риска развития аллергического ринита и бронхиальной астмы, а также в значительном степени определяет формирование тяжелых форм атопического дерматита и респираторных аллергозов. Особое значение имеет тот факт, что в отличие от других триггеров элиминация аллергенов домашних животных зачастую связана с внутренним сопротивлением со стороны пациентов. Различные аспекты рассматриваемой проблемы связаны с огромным количеством безосновательных утверждений, ведущих к неадекватной профилактике и терапии, а также негативно отражающиеся на социальной активности больных и их семей.

В статье изложены современные данные о распространенности сенсибилизации, свойствах и клиническом значении аллергенов домашних животных, изложены подходы к проведению элиминационных мероприятий.

At present, sensitization to airborne allergens in domestic animals is absolutely rightly considered one of the key risk factors for the development of allergic rhinitis and bronchial asthma, as well as largely determines the development of severe forms of atopic dermatitis and respiratory allergosis. Of particular importance is the fact that, unlike other triggers, the elimination of allergens in domestic animals is often associated with internal resistance from patients. Various aspects of this problem are associated with a large number of baseless statement that lead to inadequate prevention and therapy, as well as negatively affecting the social activity of patients and their families. The article presents the current data on the prevalence of sensitization, the properties and clinical significance of the allergens of domestic animals, outlines approaches to conducting elimination activities.

аллергиякошкасобакапрофилактикаallergycatdogpreventionReferencesRonmark E., Bjerg A., Perzanowski M., Platts-Mills T., Lundback B. Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden. // J Allergy Clin Immunol. – 2009. – V.124. - P.357–363. DOI: 10.1016/j.jaci.2009.05.011Ronmark E., Bjerg A., Perzanowski M., Platts-Mills T., Lundback B. Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden. // J Allergy Clin Immunol. – 2009. – V.124. - P.357–363. DOI: 10.1016/j.jaci.2009.05.011Linneberg A., Nielsen N.H., Madsen F., Frolund L., Dirksen A., Jorgensen T. Increasing prevalence of specific IgE to aeroallergens in an adult population: two cross-sectional surveys 8 years apart: the Copenhagen allergy study. // J Allergy Clin Immunol. – 2000. - V.106 – P.247–252. DOI: 10.1067/mai.2000.108312Linneberg A., Nielsen N.H., Madsen F., Frolund L., Dirksen A., Jorgensen T. Increasing prevalence of specific IgE to aeroallergens in an adult population: two cross-sectional surveys 8 years apart: the Copenhagen allergy study. // J Allergy Clin Immunol. – 2000. - V.106 – P.247–252. DOI: 10.1067/mai.2000.108312Bousquet P.-J., Chinn S., Janson C., Kogevinas M., Burney P., Jarvis D. Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European community respiratory health survey I. // Allergy. – 2007 – V.62(3) – P.301–309. DOI: 10.1111/j.1398-9995.2006.01293.xBousquet P.-J., Chinn S., Janson C., Kogevinas M., Burney P., Jarvis D. Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European community respiratory health survey I. // Allergy. – 2007 – V.62(3) – P.301–309. DOI: 10.1111/j.1398-9995.2006.01293.xSalo P.M., Arbes S.J. Jr, Jaramillo R., Calatroni A., Weir C.H. et al. Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. // J Allergy Clin Immunol. - 2014 – V.134 – P.350–359. DOI: 10.1053/j.ajkd.2009.01.099Salo P.M., Arbes S.J. Jr, Jaramillo R., Calatroni A., Weir C.H. et al. Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. // J Allergy Clin Immunol. - 2014 – V.134 – P.350–359. DOI: 10.1053/j.ajkd.2009.01.099Senanayake M.P., de Silva R., Jayamanna M.D., Jayasinghe J.A., Ratnayaka D., et al. Identification of aero-allergen sensitization in children seeking treatment for bronchial asthma at a tertiary care hospital for children in Sri Lanka. // Ceylon Med J. – 2014 – V.59 – P.89. DOI: 10.4038/cmj.v59i3.7469 -93.Senanayake M.P., de Silva R., Jayamanna M.D., Jayasinghe J.A., Ratnayaka D., et al. Identification of aero-allergen sensitization in children seeking treatment for bronchial asthma at a tertiary care hospital for children in Sri Lanka. // Ceylon Med J. – 2014 – V.59 – P.89. DOI: 10.4038/cmj.v59i3.7469 -93.Qi J., Zhao Y., Li W., Wang J., Zhang Y., Zhang Y. Analysis of allergens spectrum in children with allergic rhinitis in Zhengzhou district. // Lin Chung Er Bi Yan Hou Tou JingWai Ke Za Zhi. – 2015 – V.29 – P.404–406. (In Chineese). PMID: 26103656Qi J., Zhao Y., Li W., Wang J., Zhang Y., Zhang Y. Analysis of allergens spectrum in children with allergic rhinitis in Zhengzhou district. // Lin Chung Er Bi Yan Hou Tou JingWai Ke Za Zhi. – 2015 – V.29 – P.404–406. (In Chineese). PMID: 26103656Heinzerling L.M., Burbach G.J., Edenharter G., Bachert C., Bindslev-Jensen C., et al. GA(2)LEN skin test study I: GA(2) LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe. // Allergy. – 2009 – V.64 – P.1498–1506. DOI: 10.1111/j.1398-9995.2009.02093.xHeinzerling L.M., Burbach G.J., Edenharter G., Bachert C., Bindslev-Jensen C., et al. GA(2)LEN skin test study I: GA(2) LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe. // Allergy. – 2009 – V.64 – P.1498–1506. DOI: 10.1111/j.1398-9995.2009.02093.xCurin M., Reininger R., Swoboda I., Focke M., Valenta R., Spitzauer S. Skin prick test extracts for dog allergy diagnosis show considerable variations regarding the content of major and minor dog allergens. // Int Arch Allergy Immunol. – 2011 – V.154(3) – P.258-63. DOI: 10.1159/000321113Curin M., Reininger R., Swoboda I., Focke M., Valenta R., Spitzauer S. Skin prick test extracts for dog allergy diagnosis show considerable variations regarding the content of major and minor dog allergens. // Int Arch Allergy Immunol. – 2011 – V.154(3) – P.258-63. DOI: 10.1159/000321113Flohr C., Yeo L. Atopic dermatitis and the hygiene hypothesis revisited. // Curr Probl Dermatol – 2011 – V.41 – P.1-34. DOI: 10.1159/000323290Flohr C., Yeo L. Atopic dermatitis and the hygiene hypothesis revisited. // Curr Probl Dermatol – 2011 – V.41 – P.1-34. DOI: 10.1159/000323290Gehring U., Bolte G., Borte M., Bischof W., Fahlbusch B., et al. Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood. Exposure to endotoxin decreases the risk of atopic eczema in infancy: a cohort study. // J Allergy Clin Immunol – 2001 – V.108(5) – P.847-854. DOI: 10.1067/mai.2001.119026Gehring U., Bolte G., Borte M., Bischof W., Fahlbusch B., et al. Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood. Exposure to endotoxin decreases the risk of atopic eczema in infancy: a cohort study. // J Allergy Clin Immunol – 2001 – V.108(5) – P.847-854. DOI: 10.1067/mai.2001.119026Zirngibl A., Franke K., Gehring U., von Berg A, Berdel D., et al. Exposure to pets and atopic dermatitis during the first two years of life. A cohort study. // Pediatr Allergy Immunol. – 2002 – V.13(6) – P.394-401. DOI: 10.1034/j.1399-3038.2002.01110.xZirngibl A., Franke K., Gehring U., von Berg A, Berdel D., et al. Exposure to pets and atopic dermatitis during the first two years of life. A cohort study. // Pediatr Allergy Immunol. – 2002 – V.13(6) – P.394-401. DOI: 10.1034/j.1399-3038.2002.01110.xWegienka G., Johnsson C.C., Havstad S., Ownby D.R., Nicholas C., Zoratti E.M. Lifetime dog and cat exposure and dog- and cat-specific sensitization at age 18 years. // Clin Exp Allergy – 2011 – V.41(7) – P.979-986. DOI: 10.1111/j.1365-2222.2011.03747.xWegienka G., Johnsson C.C., Havstad S., Ownby D.R., Nicholas C., Zoratti E.M. Lifetime dog and cat exposure and dog- and cat-specific sensitization at age 18 years. // Clin Exp Allergy – 2011 – V.41(7) – P.979-986. DOI: 10.1111/j.1365-2222.2011.03747.xRoduit C., Wohlgensinger J., Frei R., Bitter S., Bieli C. et al. Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis. // J Allergy Clin Immunol – 2011 – V.127(1) – P.179-185. DOI: 10.1016/j.jaci.2010.10.010Roduit C., Wohlgensinger J., Frei R., Bitter S., Bieli C. et al. Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis. // J Allergy Clin Immunol – 2011 – V.127(1) – P.179-185. DOI: 10.1016/j.jaci.2010.10.010Langan S.M., Flohr C., Williams H.C. The role of furry pets in eczema: a systematic review. // Arch Dermatol – 2007 – V.143(12) – P.1570-1577. DOI: 10.1001/archderm.143.12.1570Langan S.M., Flohr C., Williams H.C. The role of furry pets in eczema: a systematic review. // Arch Dermatol – 2007 – V.143(12) – P.1570-1577. DOI: 10.1001/archderm.143.12.1570Custovic A., Simpson B.M., Simpson A., Kissen P., Woodcock A. Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomized trial. // Lancet – 2001 – V.358 – P.188– 193. DOI: 10.1097/00006254-200201000-00010Custovic A., Simpson B.M., Simpson A., Kissen P., Woodcock A. Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomized trial. // Lancet – 2001 – V.358 – P.188– 193. DOI: 10.1097/00006254-200201000-00010Koopman L.P., van Strien R.T., Kerkhof M., Wijga A., Smit H.A. et al. Placebo-controlled trial of house dust miteimpermeable mattress covers. // Am J Respir Crit Care Med - 2002 – V.166 – P.307–313. DOI: 10.1164/rccm.2106026Koopman L.P., van Strien R.T., Kerkhof M., Wijga A., Smit H.A. et al. Placebo-controlled trial of house dust miteimpermeable mattress covers. // Am J Respir Crit Care Med - 2002 – V.166 – P.307–313. DOI: 10.1164/rccm.2106026Capristo C., Romei I., Boner A.L. Environmental prevention in atopic eczema dermatitis syndrome (AEDS) and asthma: avoidance of indoor allergens. // Allergy – 2004 – V.59(78) – P.53-60. DOI: 10.1111/j.1398-9995.2004.00652.xCapristo C., Romei I., Boner A.L. Environmental prevention in atopic eczema dermatitis syndrome (AEDS) and asthma: avoidance of indoor allergens. // Allergy – 2004 – V.59(78) – P.53-60. DOI: 10.1111/j.1398-9995.2004.00652.xChen C.M., Sausenthaler S., Bischof W., Herbarth O., Borte M. et al. Perinatal exposure to endotoxin and the development of eczema during the first 6 years of life. // Clin Exp Dermatol. – 2010 – V.35 (3) – P.238-244. DOI: 10.1111/j.1365-2230.2009.03460.xChen C.M., Sausenthaler S., Bischof W., Herbarth O., Borte M. et al. Perinatal exposure to endotoxin and the development of eczema during the first 6 years of life. // Clin Exp Dermatol. – 2010 – V.35 (3) – P.238-244. DOI: 10.1111/j.1365-2230.2009.03460.xLodge C.J., Allen K.J., Lowe A.J., Hill D.J., Hosking C.S. et al. Perinatal cat and dog exposure and the risk of asthma and allergy in the urbanenvironment: a systematic review of longitudinal studies. // Clin Dev Immunol – 2012 – V.2012 – P.1-10. DOI: 10.1155/2012/176484Lodge C.J., Allen K.J., Lowe A.J., Hill D.J., Hosking C.S. et al. Perinatal cat and dog exposure and the risk of asthma and allergy in the urbanenvironment: a systematic review of longitudinal studies. // Clin Dev Immunol – 2012 – V.2012 – P.1-10. DOI: 10.1155/2012/176484Pelucchi C., Galeone C., Bach J.F., La Vecchia C., Chatenoud L. Pet exposure and risk of atopic dermatitis at the pediatric age: a meta-analysis of birth cohort studies. // J Allergy Clin Immunol. - 2013 – V.132(3) – P.616-622. DOI: 10.1016/j.jaci.2013.04.009Pelucchi C., Galeone C., Bach J.F., La Vecchia C., Chatenoud L. Pet exposure and risk of atopic dermatitis at the pediatric age: a meta-analysis of birth cohort studies. // J Allergy Clin Immunol. - 2013 – V.132(3) – P.616-622. DOI: 10.1016/j.jaci.2013.04.009Bremmer S.F., Simpson E.L. Dust mite avoidance for the primary prevention of atopic dermatitis: a systematic review and meta-analysis. // Pediatr Allergy Immunol – 2015 – V.26 – P.646-654. DOI: 10.1111/pai.12452Bremmer S.F., Simpson E.L. Dust mite avoidance for the primary prevention of atopic dermatitis: a systematic review and meta-analysis. // Pediatr Allergy Immunol – 2015 – V.26 – P.646-654. DOI: 10.1111/pai.12452Haftenberger M., Laußmann D., Ellert U., Kalcklösch M., Langen U. et al. Prevalence of sensitisation to aeroallergens and food llergens: results of the German Health Interview and Examination Survey for Adults (DEGS1). // Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz – 2013 – V.56 – P.687-697. DOI: 10.3390/pharmacy6020052Haftenberger M., Laußmann D., Ellert U., Kalcklösch M., Langen U. et al. Prevalence of sensitisation to aeroallergens and food llergens: results of the German Health Interview and Examination Survey for Adults (DEGS1). // Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz – 2013 – V.56 – P.687-697. DOI: 10.3390/pharmacy6020052Björnsdottir U.S., Jakobinudottir S., Runarsdottir V., Juliusson S. The effect of reducing levels of cat allergen (Fel d 1) on clinical symptoms in patients with cat allergy. // Ann Allergy AsthmaImmunol. – 2003 - V.91 – P.189–194. DOI: 10.1016/s1081-1206(10)62176-xBjörnsdottir U.S., Jakobinudottir S., Runarsdottir V., Juliusson S. The effect of reducing levels of cat allergen (Fel d 1) on clinical symptoms in patients with cat allergy. // Ann Allergy AsthmaImmunol. – 2003 - V.91 – P.189–194. DOI: 10.1016/s1081-1206(10)62176-xCarayol N., Birnbaum J., Magnan A., Ramadour M., Lanteaume A. et al. Fel d 1 production in the cat skin varies according to anatomical sites. // Allergy. – 2000 – V.55 – P.570–573. DOI: 10.1034/j.1398-9995.2000.00588.xCarayol N., Birnbaum J., Magnan A., Ramadour M., Lanteaume A. et al. Fel d 1 production in the cat skin varies according to anatomical sites. // Allergy. – 2000 – V.55 – P.570–573. DOI: 10.1034/j.1398-9995.2000.00588.xAvner DB, Perzanowski MS, Platts-Mills TA, Woodfolk JA. Evaluation of different techniques for washing cats: quantitation of allergen removed from the cat and the effect on airborne Fel d 1. // J Allergy Clin Immunol. – 1997 – V.100 – P.307–312.Avner DB, Perzanowski MS, Platts-Mills TA, Woodfolk JA. Evaluation of different techniques for washing cats: quantitation of allergen removed from the cat and the effect on airborne Fel d 1. // J Allergy Clin Immunol. – 1997 – V.100 – P.307–312.https://doi.org/10.1016/s0091-6749(97)70242-2https://doi.org/10.1016/s0091-6749(97)70242-2Nageotte C., Park M., Havstad S., Zoratti E., Ownby D. Duration of airborne Fel d 1 reduction after cat washing. // J Allergy Clin Immunol. – 2006 – V.118 – P.521–522. DOI: 10.1016/j.jaci.2006.04.049Nageotte C., Park M., Havstad S., Zoratti E., Ownby D. Duration of airborne Fel d 1 reduction after cat washing. // J Allergy Clin Immunol. – 2006 – V.118 – P.521–522. DOI: 10.1016/j.jaci.2006.04.049Satyaraj E, Gardner C, Filipi I, Cramer K, Sherrill S. Reduction of active Fel d1 from cats using an antiFel d1 egg IgY antibody. // Immun Inflamm Dis. – 2019 – V.7(2) – P.68-73. https://doi.org/10.1002/iid3.244Satyaraj E, Gardner C, Filipi I, Cramer K, Sherrill S. Reduction of active Fel d1 from cats using an antiFel d1 egg IgY antibody. // Immun Inflamm Dis. – 2019 – V.7(2) – P.68-73. https://doi.org/10.1002/iid3.244Lanzarini N M, Bentes GA, Volotão EM, Pinto MA. Use of chicken immunoglobulin Y in general virology. // Journal Of Immunoassay & Immunochemistry. - 2018. - V.39 - P. 235-248. https://doi.org/10.1080/15321819.2018.1500375Lanzarini N M, Bentes GA, Volotão EM, Pinto MA. Use of chicken immunoglobulin Y in general virology. // Journal Of Immunoassay & Immunochemistry. - 2018. - V.39 - P. 235-248. https://doi.org/10.1080/15321819.2018.1500375Larsson A, Bålöw RM, Lindahl TL, Forsberg PO. Chicken antibodies: taking advantage of evolution--a review. // Poultry Science. - 1993. – V.72 - P.1807-1812. https://doi.org/10.3382/ps.0721807Larsson A, Bålöw RM, Lindahl TL, Forsberg PO. Chicken antibodies: taking advantage of evolution--a review. // Poultry Science. - 1993. – V.72 - P.1807-1812. https://doi.org/10.3382/ps.0721807Gherasim A, de Blay F. Does Air Filtration Work for Cat Allergen Exposure? // Curr Allergy Asthma Rep. – 2020 – V.20(6) – P.18. https://doi.org/10.1007/s11882-020-00912-wGherasim A, de Blay F. Does Air Filtration Work for Cat Allergen Exposure? // Curr Allergy Asthma Rep. – 2020 – V.20(6) – P.18. https://doi.org/10.1007/s11882-020-00912-wGore RB, Bishop S, Durrell B, Curbishley L, Woodcock A, Custovic A. Air filtration units in homes with cats: can they reduce personal exposure to cat allergen? // Clin Exp Allergy. – 2003 – V.33 – P.765–769. https://doi.org/10.1046/j.1365-2222.2003.01678.xGore RB, Bishop S, Durrell B, Curbishley L, Woodcock A, Custovic A. Air filtration units in homes with cats: can they reduce personal exposure to cat allergen? // Clin Exp Allergy. – 2003 – V.33 – P.765–769. https://doi.org/10.1046/j.1365-2222.2003.01678.xvan der Heide S, van AalderenWM, Kauffman HF, Dubois AE, de Monchy JG. Effects of air cleaners in homes of asthmatic children sensitized to pet allergens. // J Allergy Clin Immunol. – 1999 – V.104(2 Pt 1) – P.447–451. https://doi.org/10.1016/s0091-6749(99)70391-xvan der Heide S, van AalderenWM, Kauffman HF, Dubois AE, de Monchy JG. Effects of air cleaners in homes of asthmatic children sensitized to pet allergens. // J Allergy Clin Immunol. – 1999 – V.104(2 Pt 1) – P.447–451. https://doi.org/10.1016/s0091-6749(99)70391-xWood R, Johnson E, Van Natta M, Chen P, Eggleston P. A placebo-controlled trial of a HEPA air cleaner in the treatment of cat allergy. // Am J Respir Crit Care Med. – 1998 – V.158 – P.115–120. https://doi.org/10.1164/ajrccm.158.1.9712110Wood R, Johnson E, Van Natta M, Chen P, Eggleston P. A placebo-controlled trial of a HEPA air cleaner in the treatment of cat allergy. // Am J Respir Crit Care Med. – 1998 – V.158 – P.115–120. https://doi.org/10.1164/ajrccm.158.1.9712110Gherasim A, Jacob A, Schoettel F, Domis N, de Blay F. Efficacy of air cleaners in asthmatics allergic to cat in ALYATEC® environmental exposure chamber. // Clin Exp Allergy. – 2019 – V.50 – P.1–10. https://doi.org/10.1111/cea.13511Gherasim A, Jacob A, Schoettel F, Domis N, de Blay F. Efficacy of air cleaners in asthmatics allergic to cat in ALYATEC® environmental exposure chamber. // Clin Exp Allergy. – 2019 – V.50 – P.1–10. https://doi.org/10.1111/cea.13511Poole TB. ,King SP ,Suphioglu C. Effectiveness of vacuuming and carpet washing in the removal of the major cat allergen, Fel d 1. // Allergy - 2020 – V.8. https://doi.org/10.1111/ all.14356Poole TB. ,King SP ,Suphioglu C. Effectiveness of vacuuming and carpet washing in the removal of the major cat allergen, Fel d 1. // Allergy - 2020 – V.8. https://doi.org/10.1111/ all.14356

The authors declare that there are no conflicts of interest present.