mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2020-11-4-6-23mvjr-1302Research ArticleОБЗОРЫREVIEWОжирение = воспаление. Патогенез. Чем это грозит мужчинам?Obesity = inflammation. Pathogenesis. How does this threaten men?https://orcid.org/0000-0001-7954-0437ПавловаЗ. Ш.PavlovaZ. Sh.

к.м.н., врач-эндокринолог, старший научный сотрудник отдела возрастассоциированных заболеваний,

Москва

Cand. Sci. (Med.), Endocrinologist, Senior Researcher, Department of Age-Associated Diseases, 

Moscow

zukhra73@gmail.comhttps://orcid.org/0000-0003-0935-9004ГолодниковИ. И.GolodnikovI. I.

врач-ординатор, кафедра эндокринологии, 

Москва

Resident Physician, Department of Endocrinology, 

Moscow

golodnikov@yahoo.comМедицинский научно-образовательный центр Московского государственного университета имени М.В. ЛомоносоваРоссияMedical Scientific-Educational Center of Lomonosov Moscow State UniversityRussian FederationРоссийская медицинская академия непрерывного профессионального образованияРоссияRussian Medical Academy of Continuing Professional EducationRussian Federation202020122020114623Copyright © Павлова З.Ш., Голодников И.И., 20202020Павлова З.Ш., Голодников И.И.Pavlova Z.S., Golodnikov I.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1302

На сегодняшний день жировая ткань перестала восприниматься только как энергетическая субстанция с присущими ей свойствами в виде терморегуляции и механической защиты, известными с начала двадцатого века. Жировая ткань — это полноценный эндокринный орган, который распределен по всему организму. Полноценность его работы напрямую влияет на энергетический баланс не только посредством участия в обмене углеводов и жиров, но и продукцией множества адипокинов, общим числом более 600, известных на сегодняшний день. В данном обзоре разбирается причинно-следственная связь субклинического или системного воспаления жировой ткани с избытком энергетических ресурсов, инсулинорезистентностью, лептином, адипонектином, метаболитами эстрогенов и одним из наиболее провосполительных цитокинов интерлейкином 6. Также внимание уделено связи рака предстательной железы и ожирения как неоднозначной связи из-за максимально прикованного к тестостерону внимания. Дальнейшее изучение жировой ткани позволит установить конкретные патофизиологические механизмы ответственные за развитие не только нарушений углеводного обмена, но и ряда других систем ввиду не до конца понятного системного действия адипокинов и связанных с ними медиаторов воспаления у лиц с ожирением. Системный поиск литературы проводился по базам данных Medline, Scopus, Web of Science и elibrary.

Today, adipose tissue has ceased to be perceived only as an energetic substance with its intrinsic properties in the form of thermoregulation and mechanical protection, known since the beginning of the twentieth century. Today, adipose tissue is a fullfledged endocrine organ that is distributed throughout the body — the usefulness of its work directly affects the energy balance, not only through involvement in the metabolism of carbohydrates and fats, but also by the production of many adipokines, a total of more than 600 known today. This review research the causal relationship of subclinical or systemic inflammation of adipose tissue with an excess of energy resources, insulin resistance, leptin, adiponectin, estrogen metabolites and one of the most pro-inflammatory cytokines - interleukin 6. Attention is also paid to the relationship between prostate cancer and obesity, as an ambiguous relationship due to the maximum paying attention to testosterone. Further study of adipose tissue will make it possible to establish specific pathophysiological mechanisms responsible for the development of not only disorders of carbohydrate metabolism, but also a number of other systems in view of the not fully understood systemic action of adipokines and associated inflammatory mediators in obese individuals. Systematic literature search was perform in the Medline, Scopus, Web of Science and elibrary databases.

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The authors declare that there are no conflicts of interest present.