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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mvjr</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский вестник Юга России</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Herald of the South of Russia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2219-8075</issn><issn pub-type="epub">2618-7876</issn><publisher><publisher-name>The Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">mvjr-1227</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Старение организма – универсальная болезнь или неизбежно возникающий процесс?</article-title><trans-title-group xml:lang="en"><trans-title>Organism Ageing – Universal Illness or Inevitably Arising Process?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ишонина</surname><given-names>О. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Ishonina</surname><given-names>O. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра медицинской биологии и генетики</p><p>344022, г. Ростов-на-Дону, пер.Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Medical Biology and Genetics Department</p><p>29 Nakhichevansky st., Rostov-on-Don, 344022</p></bio><email xlink:type="simple">oks-ishonina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ростовский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2011</year></pub-date><volume>0</volume><issue>3</issue><fpage>9</fpage><lpage>12</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ишонина О.Г., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Ишонина О.Г.</copyright-holder><copyright-holder xml:lang="en">Ishonina O.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medicalherald.ru/jour/article/view/1227">https://www.medicalherald.ru/jour/article/view/1227</self-uri><abstract><p>В статье приведён литературный обзор изучения проблемы старения как процесса нормальных или физиологических, так и патологических возрастных изменений. Сегодня не существует единой точки зрения на процессы старения, но понятно, что в основе старения лежит внутренняя нестабильность биологических молекул. Некоторые авторы видят старение во взаимоотношениях с ассоциированными с возрастом болезнями. Другие авторы старение определяют как самую универсальную болезнь, и под нормальным старением понимают сумму и переплетение десяти главных болезней, порождаемых онтогенетическими и аккумуляционными механизмами. Понятно, что нет заболевания, которое было бы причиной смерти у всех старых индивидов, но различают заболевания, связанные со старением, и заболевания, связанные с возрастом.</p></abstract><trans-abstract xml:lang="en"><p>The paper presents a literature review study of aging as a process of normal or physiological and pathological age-related changes. Today there is no single perspective on the aging process, but it is clear that the basis of aging is the internal instability of biological molecules. Some authors see the relationship with aging-associated disease age. Other authors define aging as the most universal disease, and under normal aging understand the amount and intertwining of the top ten diseases generated by ontogenetic and accumulation mechanisms. It is clear that there is no disease that would have been the cause of death for all older individuals, but also distinguish the disease associated with aging (aging-dependent), and diseases associated with age (age-dependent).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>нормальное (физиологическое) старение</kwd><kwd>патологическое старение</kwd><kwd>болезни</kwd><kwd>ассоциированные с возрастом</kwd></kwd-group><kwd-group xml:lang="en"><kwd>normal (physiological) aging</kwd><kwd>pathological aging</kwd><kwd>disease associated with aging</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Finch C.E. Longevity, Senescence, and the Genome. - Chicago: Univ. Chicago Press, 1990.</mixed-citation><mixed-citation xml:lang="en">Finch C.E. Longevity, Senescence, and the Genome. - Chicago: Univ. Chicago Press, 1990.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Лазебник Л.Б. Полиморбидность и старение //Клиническая геронтология. - № 12. - 2005. - С.16-22.</mixed-citation><mixed-citation xml:lang="en">Лазебник Л.Б. Полиморбидность и старение //Клиническая геронтология. - № 12. - 2005. - С.16-22.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Shock N. W. Physiological aspects of aging in man // Ann. Rev. Physiol.- 1961.- V. 23.- P. 97 - 122.</mixed-citation><mixed-citation xml:lang="en">Shock N. W. Physiological aspects of aging in man // Ann. Rev. Physiol.- 1961.- V. 23.- P. 97 - 122.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Evans J.G. In: Research and the Aging Population. Evered D., Whalen J., eds. - Chichester: Wiley, 1988. - P.38-57.</mixed-citation><mixed-citation xml:lang="en">Evans J.G. In: Research and the Aging Population. Evered D., Whalen J., eds. - Chichester: Wiley, 1988. - P.38-57.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Blumenthal H. T. The autopsy in gerontological research: a retrospective // J. Gerontol.Biol. Sci. - 2003. - Vol. 58 A. - P. 138—145.</mixed-citation><mixed-citation xml:lang="en">Blumenthal H. T. The autopsy in gerontological research: a retrospective // J. Gerontol.Biol. Sci. - 2003. - Vol. 58 A. - P. 138—145.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Adelman R.C. In: Second Conference on the Epidemiolo gy of Aging. Haynes S.G., Feinleib M., eds. - Washington, DC: National Institute of Health. 1980, pp. 9-13. NIH Publication 80-969.</mixed-citation><mixed-citation xml:lang="en">Adelman R.C. In: Second Conference on the Epidemiolo gy of Aging. Haynes S.G., Feinleib M., eds. - Washington, DC: National Institute of Health. 1980, pp. 9-13. NIH Publication 80-969.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Gerhard G. S., Cristofalo V. J. The limits of biogerontology / The Biology of Aging / Eds R. L. Sprott, H. R. Warner, T. F. Williams. N. Y.: Springer, 1993. P. 107—118.</mixed-citation><mixed-citation xml:lang="en">Gerhard G. S., Cristofalo V. J. The limits of biogerontology / The Biology of Aging / Eds R. L. Sprott, H. R. Warner, T. F. Williams. N. Y.: Springer, 1993. P. 107—118.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Мечников И.И. Этюды оптимизма. - М.: Наука. 1988.</mixed-citation><mixed-citation xml:lang="en">Мечников И.И. Этюды оптимизма. - М.: Наука. 1988.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Горев Н.Н., Фролькис В.В., Фудель-Осипова С.И. В кн.: Механизмы старения /Под ред. Д.Ф. Чеботарева и др. - Киев: Гос. мед. изд-во УССР, 1963. - С.5-18.</mixed-citation><mixed-citation xml:lang="en">Горев Н.Н., Фролькис В.В., Фудель-Осипова С.И. В кн.: Механизмы старения /Под ред. Д.Ф. Чеботарева и др. - Киев: Гос. мед. изд-во УССР, 1963. - С.5-18.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Фролькис В.В. Старение и старость. В кн.: Биология старения. - Л.: Наука, 1982. - С.5-23.</mixed-citation><mixed-citation xml:lang="en">Фролькис В.В. Старение и старость. В кн.: Биология старения. - Л.: Наука, 1982. - С.5-23.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hayflick L. The not so close relationship between biological aging and age associated pathologies in humans // J. Gerontol. Biol. Sci. - 2004. - Vol. 59A. — P. 547–550.</mixed-citation><mixed-citation xml:lang="en">Hayflick L. The not so close relationship between biological aging and age associated pathologies in humans // J. Gerontol. Biol. Sci. - 2004. - Vol. 59A. — P. 547–550.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">А.К.Терман. Сущность и взаимосвязь понятий «жизнь», «болезнь», «старение» //Физиологический журнал. - 1991. - Т. 37, № 3. - С.119-127.</mixed-citation><mixed-citation xml:lang="en">А.К.Терман. Сущность и взаимосвязь понятий «жизнь», «болезнь», «старение» //Физиологический журнал. - 1991. - Т. 37, № 3. - С.119-127.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ludwig F.C., Smoke M.E. The measurement of biological age // Exp. Aging Res. - 1980. - 6, N 6. - P.497-522.</mixed-citation><mixed-citation xml:lang="en">Ludwig F.C., Smoke M.E. The measurement of biological age // Exp. Aging Res. - 1980. - 6, N 6. - P.497-522.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Дильман В.М. Четыре модели медицины. - М.: Медицина. 1987.</mixed-citation><mixed-citation xml:lang="en">Дильман В.М. Четыре модели медицины. - М.: Медицина. 1987.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Хавинсон В.Х. Механизмы геропротекторного действия пептидов /В.Х. Хавинсон, В.Г. Морозов, В.В. Малинин // Бюлл. экспер. биол. и мед.- 2002.- Т.133, №1.- С. 4-10.</mixed-citation><mixed-citation xml:lang="en">Хавинсон В.Х. Механизмы геропротекторного действия пептидов /В.Х. Хавинсон, В.Г. Морозов, В.В. Малинин // Бюлл. экспер. биол. и мед.- 2002.- Т.133, №1.- С. 4-10.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Стрелер Б. Время, клетки, старение. - М.: ИЛ, 1966.</mixed-citation><mixed-citation xml:lang="en">Стрелер Б. Время, клетки, старение. - М.: ИЛ, 1966.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Blumenthal H. T. The autopsy in gerontological research: a retrospective // J. Gerontol. Biol. Sci. - 2003. - Vol. 58 A. - P. 138–145.</mixed-citation><mixed-citation xml:lang="en">Blumenthal H. T. The autopsy in gerontological research: a retrospective // J. Gerontol. Biol. Sci. - 2003. - Vol. 58 A. - P. 138–145.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Finch C. E. Variations in senescence and longevity including the possibility of negligible senescence // J. Gerontol. Biol. Sci. - 1998. - Vol. 53A. - P. B235—B230.</mixed-citation><mixed-citation xml:lang="en">Finch C. E. Variations in senescence and longevity including the possibility of negligible senescence // J. Gerontol. Biol. Sci. - 1998. - Vol. 53A. - P. B235—B230.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Butler R.N., Warner H.R., Williams T.F. et al. // Aging Clin. Exp. Res. – 2004. - Vol. 16. – P. 104-111.</mixed-citation><mixed-citation xml:lang="en">Butler R.N., Warner H.R., Williams T.F. et al. // Aging Clin. Exp. Res. – 2004. - Vol. 16. – P. 104-111.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">The Aging Factor in Health and Disease. Workshop Re port. - N.Y.: International Longevity Center, USA, Ltd., 1999.</mixed-citation><mixed-citation xml:lang="en">The Aging Factor in Health and Disease. Workshop Re port. - N.Y.: International Longevity Center, USA, Ltd., 1999.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Фролькис В.В. Стресс-возраст синдром //Физиологический журнал. - 1991. - Т.37, №3. - С.3-11.</mixed-citation><mixed-citation xml:lang="en">Фролькис В.В. Стресс-возраст синдром //Физиологический журнал. - 1991. - Т.37, №3. - С.3-11.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Brody J.A., Schneider E.L. Diseases and disorders of aging: an hypothesis // J. Chronic Dis. 1986. - Vol. 39. - P.871-876.</mixed-citation><mixed-citation xml:lang="en">Brody J.A., Schneider E.L. Diseases and disorders of aging: an hypothesis // J. Chronic Dis. 1986. - Vol. 39. - P.871-876.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Franceschi С. Monti D., Sansoni P. et al. The immunology of exceptional individuals: the lesson of centenarians//Immunol. Today. - 1995. - Vol. 16. - P. 12-16.</mixed-citation><mixed-citation xml:lang="en">Franceschi С. Monti D., Sansoni P. et al. The immunology of exceptional individuals: the lesson of centenarians//Immunol. Today. - 1995. - Vol. 16. - P. 12-16.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Franceschi C., Motta L., Valensin S. et al. Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians // Aging Clin. Exp. Res. 2000a. Vol.12 - .P.77-84.</mixed-citation><mixed-citation xml:lang="en">Franceschi C., Motta L., Valensin S. et al. Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians // Aging Clin. Exp. Res. 2000a. Vol.12 - .P.77-84.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Olshansky S. J., Hayflick L., Perls T. T. Anti-aging medicine: the hype and the reality — Part I // J. Gerontol. … Sci. - 2001. - Vol. 56A. - P. M67—M69.</mixed-citation><mixed-citation xml:lang="en">Olshansky S. J., Hayflick L., Perls T. T. Anti-aging medicine: the hype and the reality — Part I // J. Gerontol. … Sci. - 2001. - Vol. 56A. - P. M67—M69.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Roth G.S., Ingram D.K., Cutler R.G., Lane M.A. /Biological effects of caloric restriction in primates // Успехи геронтол. - 1999.- Т.3.- С.116-120.</mixed-citation><mixed-citation xml:lang="en">Roth G.S., Ingram D.K., Cutler R.G., Lane M.A. /Biological effects of caloric restriction in primates // Успехи геронтол. - 1999.- Т.3.- С.116-120.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Weindruch R., Sohal R.S. Caloric intake and aging // The New Engl. J. Med. - 1997. - Vol. 337. - P. 986-994.</mixed-citation><mixed-citation xml:lang="en">Weindruch R., Sohal R.S. Caloric intake and aging // The New Engl. J. Med. - 1997. - Vol. 337. - P. 986-994.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Анисимов В.Н. Молекулярные и физиологические механизмы старения. - СПб.: Наука, 2003.</mixed-citation><mixed-citation xml:lang="en">Анисимов В.Н. Молекулярные и физиологические механизмы старения. - СПб.: Наука, 2003.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Н.Я. Шабашова, О.Т. Дятченко, Р.Ш. Бахтияров, В.М. Мерабишвили. Демографические, социальные и медицинские проблемы старения населения //Вопросы онкологии. - 2001. - Т.47, №5. - С. 523-535.</mixed-citation><mixed-citation xml:lang="en">Н.Я. Шабашова, О.Т. Дятченко, Р.Ш. Бахтияров, В.М. Мерабишвили. Демографические, социальные и медицинские проблемы старения населения //Вопросы онкологии. - 2001. - Т.47, №5. - С. 523-535.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Andrews G.R., Sidorenko A., Andrianova L.F, Anisimov V.n. et al. the United nation Research Agenda on Ageing for the 21st century // Успехи геронтол. - 2001. - Т. 7. - С. 7–25.</mixed-citation><mixed-citation xml:lang="en">Andrews G.R., Sidorenko A., Andrianova L.F, Anisimov V.n. et al. the United nation Research Agenda on Ageing for the 21st century // Успехи геронтол. - 2001. - Т. 7. - С. 7–25.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">XIX Всемирный геронтологический конгресс, 5-9 июля 2009, Париж, Франция. Вестник геронтологического общества РАН. Информационный бюллетень № 8-9 (131-132), июль-август 2009. - С.1-4.</mixed-citation><mixed-citation xml:lang="en">XIX Всемирный геронтологический конгресс, 5-9 июля 2009, Париж, Франция. Вестник геронтологического общества РАН. Информационный бюллетень № 8-9 (131-132), июль-август 2009. - С.1-4.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Holliday R. The close relationship between biological aging and age-associated pathologies in humans //J. Gerontol. Biol. Sci. - 2004. - Vol. 59A. - P. 543—546.</mixed-citation><mixed-citation xml:lang="en">Holliday R. The close relationship between biological aging and age-associated pathologies in humans //J. Gerontol. Biol. Sci. - 2004. - Vol. 59A. - P. 543—546.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Stock G., Callahan D. Point-counterpoint: Would doubling the human life span be a net positive or negative for us either as individuals or as a society? //J. Gerontol. Biol. Sci. - 2004. - Vol. 59A. - P. 554–559.</mixed-citation><mixed-citation xml:lang="en">Stock G., Callahan D. Point-counterpoint: Would doubling the human life span be a net positive or negative for us either as individuals or as a society? //J. Gerontol. Biol. Sci. - 2004. - Vol. 59A. - P. 554–559.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
