mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical Universitymvjr-1226Research ArticleОБЗОРЫREVIEWРоль HELICOBACTER PYLORI в этиологии и патогенезе хронической гастродуоденальной патологииThe Role of HELICOBACTER PYLORI in Etiology and Pathogenesis of Chronic Gastroduodenal PathologyДудниковаЭ. В.DudnikovaE. V.

кафедра педиатрии с курсом неонатологии ФПК и ППС

344022, г. Ростов-на-Дону, пер. Нахичеванский, 29

Department of peadiatrics and neonatology

29 Nakhichevansky st., Rostov-on-Don, 344022

ШестопаловаМ. А.ShestopalovaM. A.

кафедра педиатрии с курсом неонатологии ФПК и ППС

344022, г. Ростов-на-Дону, пер. Нахичеванский, 29

Department of peadiatrics and neonatology

29 Nakhichevansky st., Rostov-on-Don, 344022

mari-shestopalowa@yandex.ruРостовский государственный медицинский университетРоссияRostov State Medical UniversityRussian Federation2011300920110348Copyright © Дудникова Э.В., Шестопалова М.А., 20112011Дудникова Э.В., Шестопалова М.А.Dudnikova E.V., Shestopalova M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1226

H.pylori играет важную роль в развитии хронического гастрита, пептической язвы, аденокарциномы, MALT-лимфомы. В обзоре представлены современные сведения об эпидемиологии, генетике и микробиологии данной бактерии, факторах колонизации слизистой оболочки желудка и развитии H.pylori-ассоциированных заболеваний, зависящих от внутривидового разнообразия штаммов и наличия факторов патогенности H.pylori, генетической предрасположенности, состояния местных и общих иммунных факторов защиты макроорганизма, изменений микроэкологии желудочно-кишечного тракта.

Helicobacter pylori plays a major role in the development of chronic gastritis, peptic ulcer disease, gastric adenocarcinoma, MALT-lymphoma. The review presents modern data of epidemiology, genetics and microbiology of H.pylori, about the factors of colonization of gastric mucosa and occurrence of H.pylori-associated disorders depending on the intraspecific genetic diversity and factors of pathogenecity of H.pylori, genetic predisposition, local and general protective immune factors, microecology of the gastrointestinal tract of the host.

Helicobacter pyloriпатогенезфакторы патогенностиврождённый иммунитетпробиотикиHelicobacter pyloripathogenesisfactors of pathogenecityinnate immunityprobioticsReferencesKusters J.G., van Vliet A., Kuipers E.J. Pathogenesis of Helicobacter pylori Infection //Clinical Microbiology Reviews. - 2006. - V.19(3). - P.449-490.Kusters J.G., van Vliet A., Kuipers E.J. Pathogenesis of Helicobacter pylori Infection //Clinical Microbiology Reviews. - 2006. - V.19(3). - P.449-490.Kabir S. Detection of Helicobacter pylori DNA in feces and saliva by polymerase chain reaction: a review //Helicobacter. - 2004. - V.9. - P.115-123.Kabir S. Detection of Helicobacter pylori DNA in feces and saliva by polymerase chain reaction: a review //Helicobacter. - 2004. - V.9. - P.115-123.Konno M., Fujii N., Yokota S. et al. Five-year follow-up study of mother-to-child transmission of Helicobacter pylori infection detected by a random amplified polymorphic DNA fingerprinting method //J. Clin. Microbiol. - 2005.- V.43. - P.2246-2250.Konno M., Fujii N., Yokota S. et al. Five-year follow-up study of mother-to-child transmission of Helicobacter pylori infection detected by a random amplified polymorphic DNA fingerprinting method //J. Clin. Microbiol. - 2005.- V.43. - P.2246-2250.Bunn J.E., Thomas J.E., Harding M. et al. Placental acquisition of maternal specific IgG and Helicobacter pylori colonization in infancy //Helicobacter. - 2003. - V.8(5). - P.568-72.Bunn J.E., Thomas J.E., Harding M. et al. Placental acquisition of maternal specific IgG and Helicobacter pylori colonization in infancy //Helicobacter. - 2003. - V.8(5). - P.568-72.Thomas J. E., Bunn J. E., Kleanthous H. et al. Specific immunoglobulin A antibodies in maternal milk and delayed Helicobacter pylori colonization in Gambian infants //Clin. Infect. Dis. - 2004. - V.39. - P.1155-1160.Thomas J. E., Bunn J. E., Kleanthous H. et al. Specific immunoglobulin A antibodies in maternal milk and delayed Helicobacter pylori colonization in Gambian infants //Clin. Infect. Dis. - 2004. - V.39. - P.1155-1160.Rothenbacher D., Bodeb G., Brenner H. History of breastfeeding and Helicobacter pylori infection in pre-school children: results of a population-based study from Germany //International Journal of Epidemiology. - 2002. - V.31. - P.632-637.Rothenbacher D., Bodeb G., Brenner H. History of breastfeeding and Helicobacter pylori infection in pre-school children: results of a population-based study from Germany //International Journal of Epidemiology. - 2002. - V.31. - P.632-637.Корниенко Е.А., Антонов П.В., Нажиганов О.Н. и др. О причинах вариабельности Helicobacter Pylori-ассоциированных гастродуоденальных заболеваний у детей //РМЖ. - 2003. - №11(13). - С.782-786.Корниенко Е.А., Антонов П.В., Нажиганов О.Н. и др. О причинах вариабельности Helicobacter Pylori-ассоциированных гастродуоденальных заболеваний у детей //РМЖ. - 2003. - №11(13). - С.782-786.Исаева Г.Ш., Абузарова Э.Р., Валеева Ю.В. И др. Helicobacter pylori у больных с заболеваниями гепатобилиарной системы //Журн. Микробиол. - 2009.- №2ю — С.96-101.Исаева Г.Ш., Абузарова Э.Р., Валеева Ю.В. И др. Helicobacter pylori у больных с заболеваниями гепатобилиарной системы //Журн. Микробиол. - 2009.- №2ю — С.96-101.Lundin A., Björkholm B., Kupershmidt I. et al. Slow Genetic Divergence of Helicobacter pylori Strains during Long-Term Colonization //Infection and Immunity. - 2005. - V.73(8). - P.4818-4822.Lundin A., Björkholm B., Kupershmidt I. et al. Slow Genetic Divergence of Helicobacter pylori Strains during Long-Term Colonization //Infection and Immunity. - 2005. - V.73(8). - P.4818-4822.Чернин В.В., Червинец В.М., Бондаренко В.М., Базлов С.Н. Язвенная болезнь, хронический гастрит и эзофагит в аспекте дисбактериоза эзофагогастродуоденальной зоны. - Тверь: ООО «Издательство «Триада», 2004. - 200с.Чернин В.В., Червинец В.М., Бондаренко В.М., Базлов С.Н. Язвенная болезнь, хронический гастрит и эзофагит в аспекте дисбактериоза эзофагогастродуоденальной зоны. - Тверь: ООО «Издательство «Триада», 2004. - 200с.Miles S., Piazuelo M.B., Semino-Mora C. et al. Detailed in vivo Analysis of the Role of Helicobacter pylori Fur in Colonization and Disease //Infect. Immun. - 2010. - V.78(7). - P.3072-3082.Miles S., Piazuelo M.B., Semino-Mora C. et al. Detailed in vivo Analysis of the Role of Helicobacter pylori Fur in Colonization and Disease //Infect. Immun. - 2010. - V.78(7). - P.3072-3082.Appelmelk B.J., Monteiro M.A., Martin S. L. et al. Why Helicobacter pylori has Lewis antigens //Trends Microbiol. - 2000. - V.8. - P.565-570.Appelmelk B.J., Monteiro M.A., Martin S. L. et al. Why Helicobacter pylori has Lewis antigens //Trends Microbiol. - 2000. - V.8. - P.565-570.Zhao Y., Yokota K., Ayada K. et al. Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes //J. Med. Microbiol. - 2007. - V.56. - P.154-164.Zhao Y., Yokota K., Ayada K. et al. Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes //J. Med. Microbiol. - 2007. - V.56. - P.154-164.Takata T., El-Omar E., Camorlinga M. et al. Helicobacter pylori does not require Lewis X or Lewis Y expression to colonize C3H/ HeJ. mice //Infect. Immun. - 2002. - V.70. - P.3073-3079.Takata T., El-Omar E., Camorlinga M. et al. Helicobacter pylori does not require Lewis X or Lewis Y expression to colonize C3H/ HeJ. mice //Infect. Immun. - 2002. - V.70. - P.3073-3079.Yamaoka Y., Kikuchi S., el-Zimaity H.M. et al. 2002. Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production // Gastroenterology. - 2002. - V.123. - P.414-424.Yamaoka Y., Kikuchi S., el-Zimaity H.M. et al. 2002. Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production // Gastroenterology. - 2002. - V.123. - P.414-424.Magalhães A., Reis C.A. Helicobacter pylori adhesion to gastric epithelial cells is mediated by glycan receptors //Braz. J. Med. Biol. Res. - 2010. - V.43(7). - P.611-618.Magalhães A., Reis C.A. Helicobacter pylori adhesion to gastric epithelial cells is mediated by glycan receptors //Braz. J. Med. Biol. Res. - 2010. - V.43(7). - P.611-618.Linden S.K., Wickstrom C., Lindell G. et al. Four modes of adhesion are used during Helicobacter pylori binding to human mucins in the oral and gastric niches //Helicobacter. - 2008. - V.13(2). - P.81-93.Linden S.K., Wickstrom C., Lindell G. et al. Four modes of adhesion are used during Helicobacter pylori binding to human mucins in the oral and gastric niches //Helicobacter. - 2008. - V.13(2). - P.81-93.Dowsett S.A., Kowolik M.J. Oral Helicobacter pylori: can we stomach it? //Crit. Rev. Oral. Biol. Med. - 2003. - V.14(3). - P.226-233.Dowsett S.A., Kowolik M.J. Oral Helicobacter pylori: can we stomach it? //Crit. Rev. Oral. Biol. Med. - 2003. - V.14(3). - P.226-233.Peek R.M., Jr., Fiske C., Wilson K.T. Role of Innate Immunity in Helicobacter pylori-Induced Gastric Malignancy //Physiol. Rev. - 2010. - V.90(3). - P.831-858.Peek R.M., Jr., Fiske C., Wilson K.T. Role of Innate Immunity in Helicobacter pylori-Induced Gastric Malignancy //Physiol. Rev. - 2010. - V.90(3). - P.831-858.Smythies L.E., Waites K.B. , Lindsey J.R. et al. Helicobacter pylori- induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice //J. Immunol. - 2000. - V.165. - P.1022-1029.Smythies L.E., Waites K.B. , Lindsey J.R. et al. Helicobacter pylori- induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice //J. Immunol. - 2000. - V.165. - P.1022-1029.Lee S.K., Stack A., Katzowitsch E. et al. Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5 //Microbes Infect. - 2003. - V.5. - P.1345-1356.Lee S.K., Stack A., Katzowitsch E. et al. Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5 //Microbes Infect. - 2003. - V.5. - P.1345-1356.Gobert A.P., Bambou J.C., Werts C. et al. Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism //J. Biol. Chem. - 2004. - V.279. - P.245-250.Gobert A.P., Bambou J.C., Werts C. et al. Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism //J. Biol. Chem. - 2004. - V.279. - P.245-250.Guiney D.G., Hasegawa P., Cole S.P. Helicobacter pylori preferentially induces interleukin 12 (IL-12) rather than IL-6 or IL-10 in human dendritic cells //Infect. Immun. - 2003. - V.71. - P.4163-4166.Guiney D.G., Hasegawa P., Cole S.P. Helicobacter pylori preferentially induces interleukin 12 (IL-12) rather than IL-6 or IL-10 in human dendritic cells //Infect. Immun. - 2003. - V.71. - P.4163-4166.Chen W., Shu D., Chadwick V.S. Helicobacter pylori infection: mechanism of colonization and functional dyspepsia. Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10 //J. Gastroenterol. Hepatol. - 2001. - V.16. - P.377-383.Chen W., Shu D., Chadwick V.S. Helicobacter pylori infection: mechanism of colonization and functional dyspepsia. Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10 //J. Gastroenterol. Hepatol. - 2001. - V.16. - P.377-383.Raghavan S., Fredriksson M., Svennerholm A.M. et al. Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice //Clin. Exp. Immunol. - 2003. - V.132. - P.393-400.Raghavan S., Fredriksson M., Svennerholm A.M. et al. Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice //Clin. Exp. Immunol. - 2003. - V.132. - P.393-400.Petersen A.M., Krogfelt K.A. Helicobacter pylori: an invading microorganism? A review //Immunol. Med. Microbiol. - 2003. - V.36. - P.117–126.Petersen A.M., Krogfelt K.A. Helicobacter pylori: an invading microorganism? A review //Immunol. Med. Microbiol. - 2003. - V.36. - P.117–126.Rieder G., Fischer W., Haas R. Interaction of Helicobacter pylori with host cells: function of secreted and translocated molecules // Curr. Opin. Microbiol. - 2005. - V.8. - P.67-73.Rieder G., Fischer W., Haas R. Interaction of Helicobacter pylori with host cells: function of secreted and translocated molecules // Curr. Opin. Microbiol. - 2005. - V.8. - P.67-73.Циммерман Я.С. Эволюция стратегии и тактики лечения Helicobacter pylori-зависисмых заболеваний (по материалам консенсусов «Маастрихт-1-3»): 1996-2005 //Клиническая медицина. - 2007. - №8. - С.9-14.Циммерман Я.С. Эволюция стратегии и тактики лечения Helicobacter pylori-зависисмых заболеваний (по материалам консенсусов «Маастрихт-1-3»): 1996-2005 //Клиническая медицина. - 2007. - №8. - С.9-14.Cover T.J., Blaser M.J. Helicobacter pylori in health and disease; Inverse Associations of Helicobacter pylori With Asthma and Allergy. - 2009. - V.136(6). - P.1863-73.Cover T.J., Blaser M.J. Helicobacter pylori in health and disease; Inverse Associations of Helicobacter pylori With Asthma and Allergy. - 2009. - V.136(6). - P.1863-73.Blaser M.J. Disappearing Microbiota: Helicobacter pylori Protection against Esophageal Adenocarcinoma //Cancer Prevention Research. - 2008. - V.1. - P.308-311.Blaser M.J. Disappearing Microbiota: Helicobacter pylori Protection against Esophageal Adenocarcinoma //Cancer Prevention Research. - 2008. - V.1. - P.308-311.Perry S., de Jong B.C., Solnick J.V. et al. Infection with Helicobacter pylori is associated with protection against tuberculosis //PLoS One. - 2010. - V.5(1). - P. e8804.Perry S., de Jong B.C., Solnick J.V. et al. Infection with Helicobacter pylori is associated with protection against tuberculosis //PLoS One. - 2010. - V.5(1). - P. e8804.Kim T.S., Hur J.W., Yu M.A. et al. Antagonism of Helicobacter pylori by bacteriocins of lactic acid bacteria //J. Food Prot. - 2003. - V.66. - P.3–12.Kim T.S., Hur J.W., Yu M.A. et al. Antagonism of Helicobacter pylori by bacteriocins of lactic acid bacteria //J. Food Prot. - 2003. - V.66. - P.3–12.Lesbros-Pantoflickova D., Corthésy-Theulaz I., Blum A.L. Helicobacter pylori and Probiotics //J. Nutr. - 2007. - V.137. - P.812-818.Lesbros-Pantoflickova D., Corthésy-Theulaz I., Blum A.L. Helicobacter pylori and Probiotics //J. Nutr. - 2007. - V.137. - P.812-818.Sykora J., Valeckova K., Amlerova J. et al. Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized, double-blind study // J. Clin. Gastroenterol. - 2005. - V.39. - P.692–8.Sykora J., Valeckova K., Amlerova J. et al. Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized, double-blind study // J. Clin. Gastroenterol. - 2005. - V.39. - P.692–8.Cremonini F., Di Caro S., Covino M. et al. Effect of different probiotic preparations on anti-Helicobacter pylori therapy- related side effects: a parallel group, triple blind, placebo-controlled study //Am. J. Gastroenterol. - 2002. - V.97. - P.2744–9.Cremonini F., Di Caro S., Covino M. et al. Effect of different probiotic preparations on anti-Helicobacter pylori therapy- related side effects: a parallel group, triple blind, placebo-controlled study //Am. J. Gastroenterol. - 2002. - V.97. - P.2744–9.Myllyluoma E., Veijola L., Ahlroos T. et al. Probiotic supplementation improves tolerance to Helicobacter pylori eradication therapy—a placebo-controlled, double-blind, randomized pilot study //Aliment Pharmacol Ther. - 2005. - V.21. - P.1263–72.Myllyluoma E., Veijola L., Ahlroos T. et al. Probiotic supplementation improves tolerance to Helicobacter pylori eradication therapy—a placebo-controlled, double-blind, randomized pilot study //Aliment Pharmacol Ther. - 2005. - V.21. - P.1263–72.

The authors declare that there are no conflicts of interest present.