mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical Universitymvjr-1205Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESПатогенетические аспекты невынашивания ранних сроков беременностиPathogenetic Aspects of the First Trimester MiscarriageДубровинаС. О.DubrovinaS. O.

344012 г. Ростов-на-Дону, ул. Мечникова 43

43 Mechnikova st., Rostov-on-Don, 344012

s.dubrovina@gmail.comМаклюкА. М.MaklyukA. M.

344012 г. Ростов-на-Дону, ул. Мечникова 43

43 Mechnikova st., Rostov-on-Don, 344012

ЛиндеВ. А.LindeV. A.

344012 г. Ростов-на-Дону, ул. Мечникова 43

43 Mechnikova st., Rostov-on-Don, 344012

МаркарьянИ. В.MarkaryanI. V.

344012 г. Ростов-на-Дону, ул. Мечникова 43

43 Mechnikova st., Rostov-on-Don, 344012

Ростовский научно-исследовательский институт акушерства и педиатрииРоссияRostov Scientific Research Institute of Obstetrics and PediatricsRussian Federation201130062011026368Copyright © Дубровина С.О., Маклюк А.М., Линде В.А., Маркарьян И.В., 20112011Дубровина С.О., Маклюк А.М., Линде В.А., Маркарьян И.В.Dubrovina S.O., Maklyuk A.M., Linde V.A., Markaryan I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1205Цель

Цель: на основании изучения патогенетических аспектов угрозы прерывания беременности ранних сроков разработать прогностические маркеры невынашивания беременности.

Материалы и методы

Материалы и методы: сывороточные уровни ИЛ-2 и -6, CRH, активина А, ФНО-α, СЭФР, sFlt, ФРП исследованы с помощью ELISA у 24 беременных с угрозой аборта и неблагоприятным исходом (IV группа), у 35 - с благоприятным исходом угрозы прерывания беременности (II группа), у 21 - с неразвивающейся беременностью (III группа) и 26 - с неосложненной беременностью (контрольная группа). Использованы AtteStat 7.3, MedCalc, Microsoft Excel 2003, Statistica 6.0, критерии Спирмена и Вилкоксона.

Результаты

Результаты: ИЛ-2 и 6 ниже, активин А и ФНО-α выше без статистически значимых различий в первой группе по сравнению со всеми остальными группами. Только ФНО-α во II группе статистически ниже по сравнению с I группой. Во всех группах sFlt ниже по сравнению с группой контроля. СЭФР и CRH были ниже во II и III группах и выше в IV группе по сравнению с I первой группой. ФРП был выше в III группе и ниже во II и IV группах по сравнению с I группой.

Заключение

Заключение: в первом триместре беременности у женщин с угрозой аборта с неблагоприятным исходом в сыворотке крови различия исследуемых параметров по сравнению с неосложненной беременностью и угрозой аборта с благоприятным исходом обусловливают потери беременности.

Purpose

Purpose: To examine the profile of cytokines and gormones in maternal serum of first-trimester pregnancies complicated by threatened abortion (TACP).

Materials and Methods

Materials and Methods: Serum levels of interleukin-2 and -6, tumor necrosis factor alpha (TNF-alpha), corticotropin-releasing hormone (CRH), activin A, VEGF, sFlt, PGF were measured, by ELISA, in 24 women with TACP and adverse outcome (group IV) and compared with the corresponding levels of 35 women with TACP and successful outcome (group II) and 21 miscarriage (group III) and 26 women with first-trimester uncohreatened abortionmplicated pregnancy (group I) who served as controls. AtteStat 7.3, MedCalc, Microsoft Excel 2003, Statistica 6.0, Spirmen or Wilcoxon test were used for analysis.

Results

Results: IL-2 and -6 were detected lower and TNF-alpha and activin A were detected higher with no significant difference in group I, compared to all other groups. Only TNF-alpha in group II were detected lower with significantly levels, compared to I group. sFlt in all groups was detected lower, compared to I group. VEGF and CRH were detected lower in II and III groups and higher in IV group, compared to I group. PGF was detected higher in III group and lower in II and IV groups, compared to I group.

Summary

Summary: In first-trimester TACP with adverse outcome, allteration of maternal angiogenic factors, activin A, IL and CRH levels, compared to first-trimester uncomplicated pregnancy and TACP wihreatened abortionth successful outcome, is relevant to the occurrence of miscarriages.

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The authors declare that there are no conflicts of interest present.