mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2020-11-3-40-47mvjr-1092Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESПровоспалительные цитокины у больных с острым инфарктом миокарда на фоне хронической обструктивной болезни легкихProinflammatory cytokines in patients with acute myocardial infarction against the background of chronic obstructive pulmonary diseasehttps://orcid.org/0000-0001-7874-7057НаумовА. В.NaumovA. V.

Андрей Валентинович Наумов, аспирант кафедры внутренних болезней педиатрического факультета

Астрахань

Andrey V. Naumov, Post-graduate student of the Department of Internal Diseases of Pediatric Faculty

Astrakhan

andrey.naumov.93@mail.ruhttps://orcid.org/0000-0002-3260-2677ПрокофьеваТ. В.ProkofievaT. V.

Татьяна Васильевна Прокофьева, кандидат медицинских наук, доцент кафедры внутренних болезней педиатрического факультета

Астрахань

Tatyana V. Prokofieva, Cand. Sci. (Med.), Associate Professor of the Department of Internal Diseases of Pediatric Faculty

Astrakhan

prokofeva-73@inbox.ruhttps://orcid.org/0000-0001-8299-6582ПолунинаО. С.PoluninaO. S.

Ольга Сергеевна Полунина, доктор медицинских наук, проф., заведующая кафедрой внутренних болезней педиатрического факультета

Астрахань

Olga S. Polunina, Dr. Sci. (Med.), Professor, Head of the Department of Internal Diseases of Pediatric Faculty

Astrakhan

admed@yandex.ruhttps://orcid.org/0000-0002-4426-3860СароянцЛ. В.SaroyantsL. V.

Людмила Валентиновна Сароянц, доктор медицинских наук, заведующая лабораторно-экспериментальным отделом

Астрахань

Lyudmila V. Saroyants, Dr. Sci. (Med.), head of the Laboratory and Experimental Department

Astrakhan

luda_saroyants@mail.ruhttps://orcid.org/0000-0002-3679-432XПолунинаЕ. А.PoluninaE. A.

Екатерина Андреевна Полунина, доктор медицинских наук, доцент кафедры внутренних болезней педиатрического факультета

Астрахань

Ekaterina A. Polunina, Dr. Sci. (Med.), Associate Professor of the Department of Internal Diseases of Pediatric Faculty

Astrakhan

gilti2@yandex.ruАстраханский государственный медицинский университетРоссияAstrakhan State Medical UniversityRussian FederationНаучно-исследовательский институт по изучению лепрыРоссияScientific research Institute for the study of leprosyRussian Federation2020250920201134047Copyright © Наумов А.В., Прокофьева Т.В., Полунина О.С., Сароянц Л.В., Полунина Е.А., 20202020Наумов А.В., Прокофьева Т.В., Полунина О.С., Сароянц Л.В., Полунина Е.А.Naumov A.V., Prokofieva T.V., Polunina O.S., Saroyants L.V., Polunina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1092Цель

Цель: изучить и проанализировать сывороточный уровень интерлейкинов (ИЛ) ИЛ-1β, ИЛ-2 и ИЛ-6 у больных с острым инфарктом миокарда на фоне хронической обструктивной болезни легких.

Материалы и методы

Материалы и методы: всего обследовано 85 человек: 28 больных инфарктом миокарда, 37 больных коморбидной патологией (инфаркт миокарда на фоне хронической обструктивной болезни легких) и 20 соматически здоровых добровольца в качестве группы контроля. Определение уровней ИЛ-1β, ИЛ-2 и ИЛ-6 проведено методом твердофазного иммуноферментного анализа.

Результаты

Результаты: в группе больных инфарктом миокарда и у больных коморбидной патологией выявлено статистически значимое повышение уровня изучаемых цитокинов по сравнению с группой контроля. Самые высокие уровни ИЛ-1β, ИЛ-2 и ИЛ-6 определялись в группе больных с коморбидной патологией. Установлено, что IL-6 является независимым маркером повышенного риска инфаркта миокарда с подъемом сегмента ST, а увеличение его концентрации позже 12 часов от момента поступления связано с риском будущей сердечно-сосудистой смерти или повторного инфаркта миокарда.

Заключение

Заключение: анализ динамики уровня ИЛ-1β, ИЛ-2 и ИЛ-6 обладает высокой прогностической значимостью как у больных с инфарктом миокарда, так и у больных с коморбидной патологией.

Objective

Objective: To study and analyze serum levels of interleukins (IL): IL-1β, IL-2 and IL-6 in patients with myocardial infarction and chronic obstructive pulmonary disease.

Materials and methods

Materials and methods: In 85 people were examined: 28 patients with myocardial infarction, 37 patients with comorbid pathology (myocardial infarction and chronic obstructive pulmonary disease) and 20 somatically healthy volunteers as a control group. Determination of IL-1β, IL-2 and IL-6 levels was basing on enzyme immunoassay.

Results

Results: The median and inter-percentile range of IL-1β, IL-2 and IL-6 in the donors did not differ significantly from the data of the manufacturer. In the group of patients with myocardial infarction and in patients with comorbid pathology a statistically significant increase in the level of median and inter-percentile range of cytokines was revealing compared with the control group. The highest levels of IL-1β, IL-2 and IL-6 were detecting in the group of patients with comorbid pathology. IL-6 was found to be an independent marker of increased risk of STEMI and an increase in its concentration later than 12 hours after hospitalization is associated with the risk of future cardiovascular death or new myocardial infarction.

Conclusion

Conclusion: Analysis of the dynamics of the level of IL-1β, IL-2 and IL-6 has a high prognostic value in patients with myocardial infarction and in patients with comorbid pathology.

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The authors declare that there are no conflicts of interest present.