mvjrМедицинский вестник Юга РоссииMedical Herald of the South of Russia2219-80752618-7876The Rostov State Medical University10.21886/2219-8075-2020-11-2-6-18mvjr-1062Research ArticleОБЗОРЫREVIEWРоль цитокинов в ремоделировании костной ткани и патогенезе постменопаузального остеопорозаThe role of cytokines in bone remodeling and the pathogenesis of postmenopausal osteoporosishttps://orcid.org/0000-0003-3611-1186ИгнатенкоГ. А.IgnatenkoG. A.

Игнатенко Григорий Анатольевич, д.м.н., профессор, заведующий кафедрой пропедевтической и внутренней медицины

Донецк, ДНР

Grigory A. Ignatenko, Dr. Sci. (Med.), Professor, head of the Department of propaedeutic and internal medicine

Donetsk, DPR

prop-vnutr-medicina@dnmu.ruhttps://orcid.org/0000-0001-9436-6406НемсадзеИ. Г.NemsadzeI. G.

Немсадзе Илона Гурамовна, ассистент кафедры акушерства и гинекологии

Донецк, ДНР

Ilona G. Nemsadze, Assistant of the Department of Obstetrics and Gynecology

Donetsk, DPR

inemsadze@bk.ruhttps://orcid.org/0000-0003-3611-1186МировичЕ. Д.MirovichE. D.

Мирович Евгений Давидович, д.м.н., профессор кафедры акушерства и гинекологии

Донецк, ДНР

Evgeny D. Mirovich, Dr. Sci. (Med.), Professor of the Department of Obstetrics and Gynecology

Donetsk, DPR

Ipmirov@mail.ruhttps://orcid.org/0000-0003-2420-7156ЧуриловА. В.ChurilovA. V.

Чурилов Андрей Викторович,  д.м.н., профессор, заведующий кафедрой акушерства и гинекологии

Донецк, ДНР

Andrey V. Churilov, Dr. Sci. (Med.), Professor, head of the Department of Obstetrics and Gynecology

Donetsk, DPR

Prof.churilovav@gmail.comhttps://orcid.org/0000-0003-2845-7750МайлянЭ. А.MaylyanE. A.

Майлян Эдуард Апетнакович, д.м.н., профессор кафедры клинической иммунологии, аллергологии и эндокринологии

Донецк, ДНР

Edward A. Maylyan, Dr. Sci. (Med.), Professor, Department of Clinical Immunology, Allergology and Endocrinology

Donetsk, DPR

mea095@yandex.ruhttps://orcid.org/0000-0003-4027-8835ГлазковА. Э.GlazkovI. S.

Глазков Илья Сергеевич, д.м.н., главный врач

Симферополь

Ilya S. Glazkov, Dr. Sci. (Med.), Head of the Simferopol Clinical Maternity Hospital No. 2

Simferopol

rd2head@mail.ruhttps://orcid.org/0000-0002-1711-021XРумянцеваЗ. С.RumyantcevaZ. S.

Румянцева Зоя Сергеевна, к.м.н., заведующая кафедрой акушерства, гинекологии и перинатологии №1

Симферополь

Zoya S. Rumyantseva, Cand. Sci. (Med.), associate Professor, head of the Department of Obstetrics, Gynecology and Perinatology No. 1 of S.I. Georgievsky Medical Academy, Vernadsky CFU

Simferopol

zoyarum@inbox.ruДонецкий национальный медицинский университет имени М. ГорькогоУкраинаM. Gorky Donetsk National Medical UniversityUkraineДонецкий национальный медицинский университет им. М.ГорькогоУкраинаM. Gorky Donetsk National Medical UniversityUkraineСимферопольский клинический родильный дом № 2РоссияSimferopol Clinical Maternity Hospital № 2Russian FederationМедицинская академия имени С.И. ГеоргиевскогоРоссияS.I. Georgievsky Medical Academy named afterRussian Federation202030062020112618Copyright © Игнатенко Г.А., Немсадзе И.Г., Мирович Е.Д., Чурилов А.В., Майлян Э.А., Глазков А.Э., Румянцева З.С., 20202020Игнатенко Г.А., Немсадзе И.Г., Мирович Е.Д., Чурилов А.В., Майлян Э.А., Глазков А.Э., Румянцева З.С.Ignatenko G.A., Nemsadze I.G., Mirovich E.D., Churilov A.V., Maylyan E.A., Glazkov I.S., Rumyantceva Z.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medicalherald.ru/jour/article/view/1062

Около 20 лет назад была обозначена новая область научных знаний – остеоиммунология, которая изучает закономерности взаимодействия иммунной и костной систем в норме и патологии. Достижения остеоиммунологии кардинально изменили наши представления о патогенезе заболеваний скелета человека, в том числе остеопороза. В настоящем обзоре литературы представлена ключевая роль цитокинов в процессах ремоделирования костной ткани в физиологических и патологических условиях. Подробно освещены вопросы взаимодействия посредством цитокинов остеобластов и остеокластов в процессе ремоделирования костной ткани. Охарактеризовано решающее значение увеличенной продукции провоспалительных цитокинов иммунокомпетентными клетками в развитии постменопаузального остеопороза. При подготовке статьи осуществлялся системный поиск литературы по базам данных Pubmed, Scopus, Web of Science, MedLine, eLIBRARY.RU и др.

About 20 years ago osteoimmunology was identified as new field of scientific knowledge. It studies patterns of immune and bone system interactions in normal and pathological conditions. The osteoimmunology achievements have fundamentally changed our ideas about the pathogenesis of human skeleton diseases, including osteoporosis. This review presents cytokines key role in physiological and pathological bone remodeling. The issues of interaction between cytokines, osteoblasts and osteoclasts are described in detail. The crucial role of proinflammatory cytokines increased production by immunocompetent cells in the postmenopausal osteoporosis development has been characterized. Pubmed, Scopus, Web of Science, MedLine, eLIBRARY.RU databases were used for systematic literature search.

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The authors declare that there are no conflicts of interest present.